Intravoxel incoherent motion magnetic resonance imaging for assessment of chronic pancreatitis with special focus on its early stage

Nobuhiro Fujita, Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Nao Fujimori, Tetsuhide Ito, Hiroshi Honda

Research output: Contribution to journalArticle

Abstract

Background: It is clinically necessary to validate a new non-invasive and reliable imaging method to detect early chronic pancreatitis. Intravoxel incoherent motion magnetic resonance imaging (MRI) is useful for quantitative assessment in abdominal solid organs. Purpose: To investigate the usefulness of intravoxel incoherent motion MRI parameters in the diagnosis of chronic pancreatitis. Material and Methods: Sixty patients with early chronic pancreatitis (n = 44) and chronic pancreatitis (n = 16) were assessed with intravoxel incoherent motion imaging. For comparison, a control group of 71 individuals without chronic pancreatitis was also enrolled. The perfusion fraction (f), pseudo-diffusion coefficient (D*), true diffusion coefficient (D), and apparent diffusion coefficient of pancreatic parenchyma were calculated. These measurements were compared between the three groups. The diagnostic accuracy of imaging parameters was assessed. Results: The f values of the early chronic pancreatitis group and the chronic pancreatitis group were significantly lower than those of the control group (P < 0.001 and P < 0.001, respectively). The D* value of the chronic pancreatitis group was significantly lower than that of the early chronic pancreatitis group (P = 0.0025). The D values of the early chronic pancreatitis group and the chronic pancreatitis group were significantly higher than those of the control group (P = 0.001 and P = 0.001, respectively). The perfusion fraction showed the highest diagnostic performance with an Az value of 0.76 for discriminating the control group from the early chronic pancreatitis and chronic pancreatitis groups. Conclusion: Intravoxel incoherent motion MRI parameters may reflect the minimal histological changes in early chronic pancreatitis.

Original languageEnglish
JournalActa Radiologica
DOIs
Publication statusAccepted/In press - Jan 1 2019

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Chronic Pancreatitis
Magnetic Resonance Imaging
Control Groups
Perfusion
Diagnostic Imaging

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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Intravoxel incoherent motion magnetic resonance imaging for assessment of chronic pancreatitis with special focus on its early stage. / Fujita, Nobuhiro; Nishie, Akihiro; Asayama, Yoshiki; Ishigami, Kousei; Fujimori, Nao; Ito, Tetsuhide; Honda, Hiroshi.

In: Acta Radiologica, 01.01.2019.

Research output: Contribution to journalArticle

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AU - Nishie, Akihiro

AU - Asayama, Yoshiki

AU - Ishigami, Kousei

AU - Fujimori, Nao

AU - Ito, Tetsuhide

AU - Honda, Hiroshi

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