Intrinsic and extrinsic regulation of mammalian hematopoiesis in the fetal liver

Anthony Swain, Tomoko Inoue, Keai Sinn Tan, Yoichi Nakanishi, Daisuke Sugiyama

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

The fetal liver (FL) is an important structure in expansion and differentiation of hematopoietic stem cells (HSC), but despite this little is known about the exact mechanisms in which FL hematopoiesis takes place. Primitive hematopoiesis gives way to definitive hematopoiesis at 12.5 dpc in mice and the process is regulated by a number of intrinsic and extrinsic factors. Intrinsic regulations are intracellular processes that have been reported to be important in the initiation of definitive hematopoiesis. Several structures are involved with extrinsic regulations of hematopoiesis within the FL, including hepatoblasts and liver sinusoidal endothelial cells (LSEC). Hepatoblasts and endothelial cells comprise separate niches involved in the extrinsic regulation of hematopoiesis. Studies have shown that co-cultures with fetal liver stromal cells can promote the expansion of erythroid cells, although the way in which stromal cells do this is still unknown. Understanding the mechanisms in which hematopoiesis is regulated in the FL could lead to the production of novel therapies involving the safe and reliable transplantation of HSCs to patients with blood and bone marrow complications. This review aims to summarize the current state of knowledge about the regulation of hematopoiesis specifically within the FL.

Original languageEnglish
Pages (from-to)1077-1082
Number of pages6
JournalHistology and histopathology
Volume29
Issue number9
Publication statusPublished - Sep 2014

Fingerprint

Hematopoiesis
Liver
Stromal Cells
Endothelial Cells
Erythroid Cells
Intrinsic Factor
Hematopoietic Stem Cells
Coculture Techniques
Transplantation
Bone Marrow

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

Cite this

Intrinsic and extrinsic regulation of mammalian hematopoiesis in the fetal liver. / Swain, Anthony; Inoue, Tomoko; Tan, Keai Sinn; Nakanishi, Yoichi; Sugiyama, Daisuke.

In: Histology and histopathology, Vol. 29, No. 9, 09.2014, p. 1077-1082.

Research output: Contribution to journalReview article

Swain, A, Inoue, T, Tan, KS, Nakanishi, Y & Sugiyama, D 2014, 'Intrinsic and extrinsic regulation of mammalian hematopoiesis in the fetal liver', Histology and histopathology, vol. 29, no. 9, pp. 1077-1082.
Swain, Anthony ; Inoue, Tomoko ; Tan, Keai Sinn ; Nakanishi, Yoichi ; Sugiyama, Daisuke. / Intrinsic and extrinsic regulation of mammalian hematopoiesis in the fetal liver. In: Histology and histopathology. 2014 ; Vol. 29, No. 9. pp. 1077-1082.
@article{ef1ed1df7c2a44318ae896c49956a7f7,
title = "Intrinsic and extrinsic regulation of mammalian hematopoiesis in the fetal liver",
abstract = "The fetal liver (FL) is an important structure in expansion and differentiation of hematopoietic stem cells (HSC), but despite this little is known about the exact mechanisms in which FL hematopoiesis takes place. Primitive hematopoiesis gives way to definitive hematopoiesis at 12.5 dpc in mice and the process is regulated by a number of intrinsic and extrinsic factors. Intrinsic regulations are intracellular processes that have been reported to be important in the initiation of definitive hematopoiesis. Several structures are involved with extrinsic regulations of hematopoiesis within the FL, including hepatoblasts and liver sinusoidal endothelial cells (LSEC). Hepatoblasts and endothelial cells comprise separate niches involved in the extrinsic regulation of hematopoiesis. Studies have shown that co-cultures with fetal liver stromal cells can promote the expansion of erythroid cells, although the way in which stromal cells do this is still unknown. Understanding the mechanisms in which hematopoiesis is regulated in the FL could lead to the production of novel therapies involving the safe and reliable transplantation of HSCs to patients with blood and bone marrow complications. This review aims to summarize the current state of knowledge about the regulation of hematopoiesis specifically within the FL.",
author = "Anthony Swain and Tomoko Inoue and Tan, {Keai Sinn} and Yoichi Nakanishi and Daisuke Sugiyama",
year = "2014",
month = "9",
language = "English",
volume = "29",
pages = "1077--1082",
journal = "Histology and Histopathology",
issn = "0213-3911",
publisher = "Histology and Histopathology",
number = "9",

}

TY - JOUR

T1 - Intrinsic and extrinsic regulation of mammalian hematopoiesis in the fetal liver

AU - Swain, Anthony

AU - Inoue, Tomoko

AU - Tan, Keai Sinn

AU - Nakanishi, Yoichi

AU - Sugiyama, Daisuke

PY - 2014/9

Y1 - 2014/9

N2 - The fetal liver (FL) is an important structure in expansion and differentiation of hematopoietic stem cells (HSC), but despite this little is known about the exact mechanisms in which FL hematopoiesis takes place. Primitive hematopoiesis gives way to definitive hematopoiesis at 12.5 dpc in mice and the process is regulated by a number of intrinsic and extrinsic factors. Intrinsic regulations are intracellular processes that have been reported to be important in the initiation of definitive hematopoiesis. Several structures are involved with extrinsic regulations of hematopoiesis within the FL, including hepatoblasts and liver sinusoidal endothelial cells (LSEC). Hepatoblasts and endothelial cells comprise separate niches involved in the extrinsic regulation of hematopoiesis. Studies have shown that co-cultures with fetal liver stromal cells can promote the expansion of erythroid cells, although the way in which stromal cells do this is still unknown. Understanding the mechanisms in which hematopoiesis is regulated in the FL could lead to the production of novel therapies involving the safe and reliable transplantation of HSCs to patients with blood and bone marrow complications. This review aims to summarize the current state of knowledge about the regulation of hematopoiesis specifically within the FL.

AB - The fetal liver (FL) is an important structure in expansion and differentiation of hematopoietic stem cells (HSC), but despite this little is known about the exact mechanisms in which FL hematopoiesis takes place. Primitive hematopoiesis gives way to definitive hematopoiesis at 12.5 dpc in mice and the process is regulated by a number of intrinsic and extrinsic factors. Intrinsic regulations are intracellular processes that have been reported to be important in the initiation of definitive hematopoiesis. Several structures are involved with extrinsic regulations of hematopoiesis within the FL, including hepatoblasts and liver sinusoidal endothelial cells (LSEC). Hepatoblasts and endothelial cells comprise separate niches involved in the extrinsic regulation of hematopoiesis. Studies have shown that co-cultures with fetal liver stromal cells can promote the expansion of erythroid cells, although the way in which stromal cells do this is still unknown. Understanding the mechanisms in which hematopoiesis is regulated in the FL could lead to the production of novel therapies involving the safe and reliable transplantation of HSCs to patients with blood and bone marrow complications. This review aims to summarize the current state of knowledge about the regulation of hematopoiesis specifically within the FL.

UR - http://www.scopus.com/inward/record.url?scp=84905667995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905667995&partnerID=8YFLogxK

M3 - Review article

C2 - 24526457

AN - SCOPUS:84905667995

VL - 29

SP - 1077

EP - 1082

JO - Histology and Histopathology

JF - Histology and Histopathology

SN - 0213-3911

IS - 9

ER -