超常磁性酸化鉄ナノパーティクル表面への蛍光性物質の導入と放出反応の検討

Translated title of the contribution: Introduction and Release of Fluorescent Chromophores on a Surface of Suoer-paramagnetic Iron Oxide Nanoparticles (SPION)

秋田 健行, 古賀 登

Research output: Contribution to journalArticle

Abstract

Chemical introduction and release of fluorescent chromophores on a surface of Super-Paramagnetic Iron Oxide Nanoparticles (SPION) were investigated. An aqueous solution of SPION having carboxylic acid and poly(ethylene glycol) groups on its surface was prepared by a reported method. A fluorescent chromophore, a derivative of fluorescein attached with aminobutenyl ether, was introduced into the SPION surface through amide bond by using of EDC. An emission of the fluorescein was quenched by introduction of the aminobutenyl ether, and the SPION solution introduced by the fluorescein derivative exhibited only weak fluorescence at ~510 nm. Once Pd(PPh<SUB>3</SUB>)<SUB>4</SUB> was added to the solution, butenyl ether bond was cleaved and release of free fluorescein was observed by increase of emission at 510 nm. This release reaction was also revealed by NMR and UV spectra of model compounds.
Translated title of the contributionIntroduction and Release of Fluorescent Chromophores on a Surface of Suoer-paramagnetic Iron Oxide Nanoparticles (SPION)
Original languageJapanese
Pages (from-to)466-466
Number of pages1
Journal基礎有機化学討論会要旨集(基礎有機化学連合討論会予稿集)
Volume2011
Issue number0
DOIs
Publication statusPublished - 2011

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