Introduction of a quaternary stereogenic center to oxindole using cholinesterase-catalyzed asymmetric hydrolysis

Koichi Nakazawa, Masaki Hayashi, Masakazu Tanaka, Mariko Aso, Hiroshi Suemune

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Prochiral diesters bearing an oxindole skeleton were efficiently prepared from oxindole. Cholinesterase-catalyzed hydrolysis of prochiral dipropionate afforded an optically active monoalcohol of 95% e.e. The obtained monoalcohol might find use as a versatile intermediate in the enantioselective synthesis of indole alkaloids.

Original languageEnglish
Pages (from-to)897-901
Number of pages5
JournalTetrahedron Asymmetry
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 17 2001

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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