Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosis

Kohei Nakata, Kenoki Ouchida, Shinichi Aishima, Yoshihiko Sadakari, Tadashi Kayashima, Yoshihiro Miyasaka, Eishi Nagai, Kazuhiro Mizumoto, Masao Tanaka, Masazumi Tsuneyoshi, Yoshinao Oda

Research output: Contribution to journalArticle

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Abstract

Objectives: Although intestinal-type intraductal papillary mucinous carcinoma (IPMC) is reported to have a better prognosis, few studies have addressed its invasive pattern. The meaning of "minimal invasion" (MI) in IPMC also remains unclear. We investigated the prognosis of intraductal papillary mucinous neoplasm (IPMN) focusing on MI and subtypes. Methods: We evaluated 71 patients with IPMC among a total of 179 patients with resected IPMN. Results: Although 2 of 10 MI-IPMC patients had lymph node metastasis, there were no disease-specific deaths among the MI-IPMC patients. Minimally invasive IPMCs were more frequently observed in intestinal-type IPMC (23/33 cases) than in non-intestinal-type IPMCs (16/38 cases; P = 0.019). Among 32 patients with massively invasive IPMC, the prognosis was significantly better for patients with intestinal-type IPMC than for patients with non-intestinal-type IPMC (P = 0.013). When confined to massively invasive IPMC, tubular invasion (P < 0.001) and lymphatic (P = 0.001) or serosal (P = 0.021) invasion were less frequently observed in intestinal-type IPMC than in non-intestinal-type IPMC. Conclusions: Invasive carcinoma derived from intestinal-type IPMN is associated with MI, colloid carcinoma, and less invasive behavior.

Original languageEnglish
Pages (from-to)581-587
Number of pages7
JournalPancreas
Volume40
Issue number4
DOIs
Publication statusPublished - May 1 2011

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Mucinous Adenocarcinoma
Carcinoma, Intraductal, Noninfiltrating
Papillary Carcinoma
Carcinoma
Neoplasms

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosis. / Nakata, Kohei; Ouchida, Kenoki; Aishima, Shinichi; Sadakari, Yoshihiko; Kayashima, Tadashi; Miyasaka, Yoshihiro; Nagai, Eishi; Mizumoto, Kazuhiro; Tanaka, Masao; Tsuneyoshi, Masazumi; Oda, Yoshinao.

In: Pancreas, Vol. 40, No. 4, 01.05.2011, p. 581-587.

Research output: Contribution to journalArticle

Nakata, Kohei ; Ouchida, Kenoki ; Aishima, Shinichi ; Sadakari, Yoshihiko ; Kayashima, Tadashi ; Miyasaka, Yoshihiro ; Nagai, Eishi ; Mizumoto, Kazuhiro ; Tanaka, Masao ; Tsuneyoshi, Masazumi ; Oda, Yoshinao. / Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosis. In: Pancreas. 2011 ; Vol. 40, No. 4. pp. 581-587.
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AU - Nakata, Kohei

AU - Ouchida, Kenoki

AU - Aishima, Shinichi

AU - Sadakari, Yoshihiko

AU - Kayashima, Tadashi

AU - Miyasaka, Yoshihiro

AU - Nagai, Eishi

AU - Mizumoto, Kazuhiro

AU - Tanaka, Masao

AU - Tsuneyoshi, Masazumi

AU - Oda, Yoshinao

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