TY - JOUR
T1 - Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women
AU - Ohnaka, Keizo
AU - Kono, Suminori
AU - Inoguchi, Toyoshi
AU - Yin, Guang
AU - Morita, Makiko
AU - Adachi, Masahiro
AU - Kawate, Hisaya
AU - Takayanagi, Ryoichi
N1 - Funding Information:
This study was supported by a grant for the 21st Century Center of Excellence (COE) Program (Kyushu University) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
PY - 2010/4
Y1 - 2010/4
N2 - Aim: The aim of this study was to examine the association of serum bilirubin, an endogenous antioxidant, with serum high sensitivity C-reactive protein (hs-CRP) level, HbA1c, and the prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women (n = 12,400). Methods: Analysis of covariance and logistic regression analysis were used to estimate geometric means of hs-CRP and HbA1c and odds ratios of prevalent diabetes according to bilirubin concentrations, respectively, with statistical adjustment for behavioral factors and liver enzymes. Results: Geometric means of hs-CRP and HbA1c were progressively lower with increasing concentrations of serum bilirubin in men and women each. An inverse association between serum bilirubin and HbA1c was slightly attenuated after adjustment for hs-CRP, but still remained highly significant (trend P = 0.0004 in men and trend P = 10-5 in women). Multivariate-adjusted odds ratios of prevalent diabetes for the lowest to highest quintiles of serum total bilirubin were 1.00, 1.00, 0.73, 0.80, and 0.73 (trend P = 0.002), without adjustment for hs-CRP, and 1.00, 1.04, 0.76, 0.86, and 0.79 (trend P = 0.01), with adjustment for hs-CRP. Conclusions: Higher concentrations of serum bilirubin probably confer protection against the development of type 2 diabetes.
AB - Aim: The aim of this study was to examine the association of serum bilirubin, an endogenous antioxidant, with serum high sensitivity C-reactive protein (hs-CRP) level, HbA1c, and the prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women (n = 12,400). Methods: Analysis of covariance and logistic regression analysis were used to estimate geometric means of hs-CRP and HbA1c and odds ratios of prevalent diabetes according to bilirubin concentrations, respectively, with statistical adjustment for behavioral factors and liver enzymes. Results: Geometric means of hs-CRP and HbA1c were progressively lower with increasing concentrations of serum bilirubin in men and women each. An inverse association between serum bilirubin and HbA1c was slightly attenuated after adjustment for hs-CRP, but still remained highly significant (trend P = 0.0004 in men and trend P = 10-5 in women). Multivariate-adjusted odds ratios of prevalent diabetes for the lowest to highest quintiles of serum total bilirubin were 1.00, 1.00, 0.73, 0.80, and 0.73 (trend P = 0.002), without adjustment for hs-CRP, and 1.00, 1.04, 0.76, 0.86, and 0.79 (trend P = 0.01), with adjustment for hs-CRP. Conclusions: Higher concentrations of serum bilirubin probably confer protection against the development of type 2 diabetes.
UR - http://www.scopus.com/inward/record.url?scp=77649232070&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77649232070&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2009.12.022
DO - 10.1016/j.diabres.2009.12.022
M3 - Article
C2 - 20083320
AN - SCOPUS:77649232070
SN - 0168-8227
VL - 88
SP - 103
EP - 110
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 1
ER -
