Investigating noise tolerance in an efficient engine for inferring biological regulatory networks

Asako Komori, Yukihiro Maki, Isao Ono, Masahiro Okamoto

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Biological systems are composed of biomolecules such as genes, proteins, metabolites, and signaling components, which interact in complex networks. To understand complex biological systems, it is important to be capable of inferring regulatory networks from experimental time series data. In previous studies, we developed efficient numerical optimization methods for inferring these networks, but we have yet to test the performance of our methods when considering the error (noise) that is inherent in experimental data. In this study, we investigated the noise tolerance of our proposed inferring engine. We prepared the noise data using the Langevin equation, and compared the performance of our method with that of alternative optimization methods.

Original languageEnglish
Article number1541006
JournalJournal of bioinformatics and computational biology
Volume13
Issue number3
DOIs
Publication statusPublished - Jun 18 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Computer Science Applications

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