Investigation of DNA strand exchange mechanisms mediated by cationic polymers.

Yuichi Sato, Won Jong Kim, Sung Won Choi, Minako Saito, Arihiro Kano, Toshihiro Akaike, Atsushi Maruyama

Research output: Contribution to journalArticle

Abstract

It was observed that conjugation of dextran for PLL provided PLL-g-Dex with new properties of enhancing and accelerating inter-nucleotide recognition (1, 2, 3). In this paper, we report the effects of cationic PLL-g-Dex copolymers on base-pair formation of self-complementary octamer oligonucleotide by using NMR and CD analysis. NMR studies revealed that PLL-g-Dex copolymer did not affect hydrogen-bondings between bases in DNA duplex. CD studies also supported inert nature of the copolymer upon hybrid structure.

Original languageEnglish
Pages (from-to)59-60
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number2
Publication statusPublished - Jan 1 2002

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Hydrogen Bonding
Dextrans
Oligonucleotides
Base Pairing
Polymers
Nucleotides
DNA

Cite this

Sato, Y., Kim, W. J., Choi, S. W., Saito, M., Kano, A., Akaike, T., & Maruyama, A. (2002). Investigation of DNA strand exchange mechanisms mediated by cationic polymers. Nucleic acids research. Supplement (2001), (2), 59-60.

Investigation of DNA strand exchange mechanisms mediated by cationic polymers. / Sato, Yuichi; Kim, Won Jong; Choi, Sung Won; Saito, Minako; Kano, Arihiro; Akaike, Toshihiro; Maruyama, Atsushi.

In: Nucleic acids research. Supplement (2001), No. 2, 01.01.2002, p. 59-60.

Research output: Contribution to journalArticle

Sato, Y, Kim, WJ, Choi, SW, Saito, M, Kano, A, Akaike, T & Maruyama, A 2002, 'Investigation of DNA strand exchange mechanisms mediated by cationic polymers.', Nucleic acids research. Supplement (2001), no. 2, pp. 59-60.
Sato, Yuichi ; Kim, Won Jong ; Choi, Sung Won ; Saito, Minako ; Kano, Arihiro ; Akaike, Toshihiro ; Maruyama, Atsushi. / Investigation of DNA strand exchange mechanisms mediated by cationic polymers. In: Nucleic acids research. Supplement (2001). 2002 ; No. 2. pp. 59-60.
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