Invitro cell viability and antibacterial activity of novel bismuth (V) complex

Sandeep Garg, Pankaj Attri, Kameshwar Sharma, Rajeev Ranjan, Parshuram Mishra

Research output: Contribution to journalArticle

Abstract

Bismuth (V) was incorporated in chloramphenicol and streptomycin keeping in view of finding new antibiotics. Formed complex was evaluated for their antibacterial and cell viability activity in mice. Murine peritoneal macrophage cell lines RAW 264.7 were used for in vitro antibacterial and cytotoxicty studies of various synthesized compounds. Bactericidal activity was assessed by Minimum inhibitory concentrations (MIC) of various compounds against different bacterial strains. Antibacterial activity of T-IV was found highest among all treatments given followed by T-III. Metal-ligand administered group showed comparatively higher in vitro cell viability than standard drug streptomycin. It was concluded that metal drug complex may have better antibiotic activity than parent antibiotics alone.

Original languageEnglish
Pages (from-to)1685-1691
Number of pages7
JournalInternational Journal of PharmTech Research
Volume1
Issue number4
Publication statusPublished - Oct 1 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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