Involvement of 5-HT(1A) receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus

Takahiro Moriya, Shiro Yamanouchi, Tatsuto Fukushima, Takao Shimazoe, Shigenobu Shibata, Shigenori Watanabe

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We examined the role of serotonin 1A (5-HT(1A)) receptors in the inhibitory effects of methamphetamine (MA) on photic entrainment to the circadian pacemaker in the suprachiasmatic nucleus (SCN) of rodents. MA inhibited optic nerve stimulation-evoked field potential in the SCN, light-induced Fos expression in the SCN and light-induced phase shift of hamster wheel-running rhythm. NAN-190, a 5-HT(1A) receptor antagonist, eliminated the inhibitory effects of MA. NAN-190 has also been reported to antagonize α1 adrenergic receptors. However, prazosin, which selectively antagonizes α1 adrenergic receptors, did not affect the inhibitory action of MA on light-induced Fos expression. In addition, parachloroamphetamine, which is known to be a 5-HT releaser, dose-dependently inhibited light-induced phase shift of wheel-running rhythm. These findings suggest that elevation of endogenous 5-HT levels by MA inhibits the photic entraining responses of the circadian pacemaker in the SCN via 5-HT(1A) receptor stimulation of the 5-HT released by MA.

Original languageEnglish
Pages (from-to)261-267
Number of pages7
JournalBrain Research
Volume740
Issue number1-2
DOIs
Publication statusPublished - Nov 18 1996

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Suprachiasmatic Nucleus
Receptor, Serotonin, 5-HT1A
Methamphetamine
Rodentia
Serotonin
Light
Running
Adrenergic Receptors
p-Chloroamphetamine
Prazosin
Optic Nerve
Evoked Potentials
Cricetinae

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Involvement of 5-HT(1A) receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus. / Moriya, Takahiro; Yamanouchi, Shiro; Fukushima, Tatsuto; Shimazoe, Takao; Shibata, Shigenobu; Watanabe, Shigenori.

In: Brain Research, Vol. 740, No. 1-2, 18.11.1996, p. 261-267.

Research output: Contribution to journalArticle

Moriya, Takahiro ; Yamanouchi, Shiro ; Fukushima, Tatsuto ; Shimazoe, Takao ; Shibata, Shigenobu ; Watanabe, Shigenori. / Involvement of 5-HT(1A) receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nucleus. In: Brain Research. 1996 ; Vol. 740, No. 1-2. pp. 261-267.
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