Involvement of Brain Cytokines in Stress-induced Immunosuppression

Toshihiko Katafuchi

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

In the brain-immune system interactions, cytokines produced in the periphery and the brain during inflammatory and noninflammatory stress play an important role as signal molecules. The central administration of interleukin-1β (IL-1β) and interferon-α (IFN-α) is shown to suppress the splenic natural killer (NK) cell activity in rats, which is mediated by, at least in part, the sympathetic innervation to the spleen. The central IL-1β and IFN-α increase the splenic sympathetic nerve activity, and an electrical stimulation of the nerve results in a suppression of splenic NK cell activity through a β-adrenergic receptor-mediated process. Furthermore, the findings that (1) immobilization (IMB) stress produced an elevation of extracellular concentration of noradrenaline in the spleen, (2) the IMB-induced reduction of splenic NK activity was partially blocked by splenic denervation, (3) pretreatment with central injection of neutralizing anti-IL-1β antibody attenuated the IMB-induced NK suppression, and (4) hypothalamic IL-1β and IFN-α mRNA were increased after 1 h IMB suggested that IL-1β and IFN-α produced in the brain may be key substances mediating the IMB stress-induced immunosuppression.

Original languageEnglish
Pages (from-to)391-401
Number of pages11
JournalNeuroImmune Biology
Volume6
Issue numberC
DOIs
Publication statusPublished - Jan 1 2008

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Interleukin-1
Immobilization
Immunosuppression
Interferons
Cytokines
Brain
Natural Killer Cells
Spleen
Denervation
Adrenergic Receptors
Electric Stimulation
Immune System
Norepinephrine
Messenger RNA
Injections
Antibodies

All Science Journal Classification (ASJC) codes

  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Involvement of Brain Cytokines in Stress-induced Immunosuppression. / Katafuchi, Toshihiko.

In: NeuroImmune Biology, Vol. 6, No. C, 01.01.2008, p. 391-401.

Research output: Contribution to journalReview article

Katafuchi, Toshihiko. / Involvement of Brain Cytokines in Stress-induced Immunosuppression. In: NeuroImmune Biology. 2008 ; Vol. 6, No. C. pp. 391-401.
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