Abstract
In the brain-immune system interactions, cytokines produced in the periphery and the brain during inflammatory and noninflammatory stress play an important role as signal molecules. The central administration of interleukin-1β (IL-1β) and interferon-α (IFN-α) is shown to suppress the splenic natural killer (NK) cell activity in rats, which is mediated by, at least in part, the sympathetic innervation to the spleen. The central IL-1β and IFN-α increase the splenic sympathetic nerve activity, and an electrical stimulation of the nerve results in a suppression of splenic NK cell activity through a β-adrenergic receptor-mediated process. Furthermore, the findings that (1) immobilization (IMB) stress produced an elevation of extracellular concentration of noradrenaline in the spleen, (2) the IMB-induced reduction of splenic NK activity was partially blocked by splenic denervation, (3) pretreatment with central injection of neutralizing anti-IL-1β antibody attenuated the IMB-induced NK suppression, and (4) hypothalamic IL-1β and IFN-α mRNA were increased after 1 h IMB suggested that IL-1β and IFN-α produced in the brain may be key substances mediating the IMB stress-induced immunosuppression.
| Original language | English |
|---|---|
| Pages (from-to) | 391-401 |
| Number of pages | 11 |
| Journal | NeuroImmune Biology |
| Volume | 6 |
| Issue number | C |
| DOIs | |
| Publication status | Published - Jan 1 2008 |
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All Science Journal Classification (ASJC) codes
- Immunology
- Neurology
- Clinical Neurology
Cite this
Involvement of Brain Cytokines in Stress-induced Immunosuppression. / Katafuchi, Toshihiko.
In: NeuroImmune Biology, Vol. 6, No. C, 01.01.2008, p. 391-401.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Involvement of Brain Cytokines in Stress-induced Immunosuppression
AU - Katafuchi, Toshihiko
PY - 2008/1/1
Y1 - 2008/1/1
N2 - In the brain-immune system interactions, cytokines produced in the periphery and the brain during inflammatory and noninflammatory stress play an important role as signal molecules. The central administration of interleukin-1β (IL-1β) and interferon-α (IFN-α) is shown to suppress the splenic natural killer (NK) cell activity in rats, which is mediated by, at least in part, the sympathetic innervation to the spleen. The central IL-1β and IFN-α increase the splenic sympathetic nerve activity, and an electrical stimulation of the nerve results in a suppression of splenic NK cell activity through a β-adrenergic receptor-mediated process. Furthermore, the findings that (1) immobilization (IMB) stress produced an elevation of extracellular concentration of noradrenaline in the spleen, (2) the IMB-induced reduction of splenic NK activity was partially blocked by splenic denervation, (3) pretreatment with central injection of neutralizing anti-IL-1β antibody attenuated the IMB-induced NK suppression, and (4) hypothalamic IL-1β and IFN-α mRNA were increased after 1 h IMB suggested that IL-1β and IFN-α produced in the brain may be key substances mediating the IMB stress-induced immunosuppression.
AB - In the brain-immune system interactions, cytokines produced in the periphery and the brain during inflammatory and noninflammatory stress play an important role as signal molecules. The central administration of interleukin-1β (IL-1β) and interferon-α (IFN-α) is shown to suppress the splenic natural killer (NK) cell activity in rats, which is mediated by, at least in part, the sympathetic innervation to the spleen. The central IL-1β and IFN-α increase the splenic sympathetic nerve activity, and an electrical stimulation of the nerve results in a suppression of splenic NK cell activity through a β-adrenergic receptor-mediated process. Furthermore, the findings that (1) immobilization (IMB) stress produced an elevation of extracellular concentration of noradrenaline in the spleen, (2) the IMB-induced reduction of splenic NK activity was partially blocked by splenic denervation, (3) pretreatment with central injection of neutralizing anti-IL-1β antibody attenuated the IMB-induced NK suppression, and (4) hypothalamic IL-1β and IFN-α mRNA were increased after 1 h IMB suggested that IL-1β and IFN-α produced in the brain may be key substances mediating the IMB stress-induced immunosuppression.
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UR - http://www.scopus.com/inward/citedby.url?scp=77957087376&partnerID=8YFLogxK
U2 - 10.1016/S1567-7443(07)10019-3
DO - 10.1016/S1567-7443(07)10019-3
M3 - Review article
AN - SCOPUS:77957087376
VL - 6
SP - 391
EP - 401
JO - NeuroImmune Biology
JF - NeuroImmune Biology
SN - 1567-7443
IS - C
ER -