Involvement of brain stem noradrenergic neurons in the development of hypertension in spontaneously hypertensive rats

Hiroshi Yao, Takashi Matsumoto, Makoto Hirano, Toshihide Kuroki, Tetsuyuki Tsutsumi, Hideyuki Uchimura, Kaoru Nakamura, Tatsuo Nakahara, Masatoshi Fujishima

Research output: Contribution to journalArticle

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Abstract

This study attempted to investigate the possible involvement of the brain stem noradrenergic system in the development of hypertension in spontaneously hypertensive rats. Steady-state norepinephrine, dopamine, serotonin and 5-hydroxyindoleacetic acid concentrations and norepinephrine turnover were determined in the individual brain stem nuclei using high performance liquid chromatography with electrochemical detection. Decreased norepinephrine contents in the nucleus tractus solitarii in spontaneously hypertensive rats compared with Wistar-Kyoto rats at the age of 4, 8, and 16 weeks were demonstrated. In later stages (8 and 16 weeks), increased norepinephrine levels were observed in the nucleus reticularis gigantocellularis, the A1 and A5 areas. Norepinephrine turnover was not different between spontaneously hypertensive rats and Wistar-Kyoto rats in the nucleus tractus solitarii at the age of 4 and 16 weeks and increased in the nucleus reticularis gigantocellularis of spontaneously hypertensive rats at 16 weeks. Our results indicate that altered norepinephrine metabolism in the specific brain stem nuclei, especially the consistently decreased norepinephrine in the nucleus tractus solitarii of spontaneously hypertensive rats, contribute to the development of genetic hypertension.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalNeurochemical Research
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 1 1989
Externally publishedYes

Fingerprint

Adrenergic Neurons
Inbred SHR Rats
Brain Stem
Neurons
Rats
Brain
Norepinephrine
Hypertension
Solitary Nucleus
Inbred WKY Rats
Hydroxyindoleacetic Acid
High performance liquid chromatography
Metabolism
Dopamine
Serotonin
High Pressure Liquid Chromatography

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Involvement of brain stem noradrenergic neurons in the development of hypertension in spontaneously hypertensive rats. / Yao, Hiroshi; Matsumoto, Takashi; Hirano, Makoto; Kuroki, Toshihide; Tsutsumi, Tetsuyuki; Uchimura, Hideyuki; Nakamura, Kaoru; Nakahara, Tatsuo; Fujishima, Masatoshi.

In: Neurochemical Research, Vol. 14, No. 1, 01.01.1989, p. 75-79.

Research output: Contribution to journalArticle

Yao, H, Matsumoto, T, Hirano, M, Kuroki, T, Tsutsumi, T, Uchimura, H, Nakamura, K, Nakahara, T & Fujishima, M 1989, 'Involvement of brain stem noradrenergic neurons in the development of hypertension in spontaneously hypertensive rats', Neurochemical Research, vol. 14, no. 1, pp. 75-79. https://doi.org/10.1007/BF00969761
Yao, Hiroshi ; Matsumoto, Takashi ; Hirano, Makoto ; Kuroki, Toshihide ; Tsutsumi, Tetsuyuki ; Uchimura, Hideyuki ; Nakamura, Kaoru ; Nakahara, Tatsuo ; Fujishima, Masatoshi. / Involvement of brain stem noradrenergic neurons in the development of hypertension in spontaneously hypertensive rats. In: Neurochemical Research. 1989 ; Vol. 14, No. 1. pp. 75-79.
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