TY - JOUR
T1 - Involvement of GABAA receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice
AU - Egashira, Nobuaki
AU - Hayakawa, Kazuhide
AU - Osajima, Megumi
AU - Mishima, Kenichi
AU - Iwasaki, Katsunori
AU - Oishi, Ryozo
AU - Fujiwara, Michihiro
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2007
Y1 - 2007
N2 - We investigated the involvement of γ-aminobutyric acidA (GABA A) receptors in the neuroprotective effect of γ- glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABAA-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABAA receptors.
AB - We investigated the involvement of γ-aminobutyric acidA (GABA A) receptors in the neuroprotective effect of γ- glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABAA-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABAA receptors.
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U2 - 10.1254/jphs.SCZ070901
DO - 10.1254/jphs.SCZ070901
M3 - Article
C2 - 17928735
AN - SCOPUS:36148971162
VL - 105
SP - 211
EP - 214
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8613
IS - 2
ER -