Involvement of GABAA receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice

Nobuaki Egashira, Kazuhide Hayakawa, Megumi Osajima, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

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70 Citations (Scopus)

Abstract

We investigated the involvement of γ-aminobutyric acidA (GABA A) receptors in the neuroprotective effect of γ- glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABAA-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABAA receptors.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalJournal of Pharmacological Sciences
Volume105
Issue number2
DOIs
Publication statusPublished - Nov 20 2007

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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