Involvement of GABAA receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice

Nobuaki Egashira; Kazuhide Hayakawa; Megumi Osajima; Kenichi Mishima; Katsunori Iwasaki; Ryozo Oishi; Michihiro Fujiwara

doi:10.1254/jphs.SCZ070901

Involvement of GABA_A receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice

Nobuaki Egashira, Kazuhide Hayakawa, Megumi Osajima, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

Pharmacy

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Abstract

We investigated the involvement of γ-aminobutyric acidA (GABA _A) receptors in the neuroprotective effect of γ- glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABA_A-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABA_A receptors.

Original language	English
Pages (from-to)	211-214
Number of pages	4
Journal	Journal of Pharmacological Sciences
Volume	105
Issue number	2
DOIs	https://doi.org/10.1254/jphs.SCZ070901
Publication status	Published - Nov 20 2007

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology

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Involvement of GABA_A receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. / Egashira, Nobuaki; Hayakawa, Kazuhide; Osajima, Megumi; Mishima, Kenichi; Iwasaki, Katsunori; Oishi, Ryozo; Fujiwara, Michihiro.

In: Journal of Pharmacological Sciences, Vol. 105, No. 2, 20.11.2007, p. 211-214.

Research output: Contribution to journal › Article › peer-review

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AU - Oishi, Ryozo

AU - Fujiwara, Michihiro

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