Involvement of GABAA receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice

Nobuaki Egashira, Kazuhide Hayakawa, Megumi Osajima, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

Research output: Contribution to journalArticle

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Abstract

We investigated the involvement of γ-aminobutyric acidA (GABA A) receptors in the neuroprotective effect of γ- glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABAA-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABAA receptors.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalJournal of Pharmacological Sciences
Volume105
Issue number2
DOIs
Publication statusPublished - Nov 20 2007

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Neuroprotective Agents
GABA-A Receptors
Brain Ischemia
Middle Cerebral Artery Infarction
3-Mercaptopropionic Acid
GABA-A Receptor Antagonists
Glutamate Decarboxylase
Bicuculline
Tea
theanine

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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Involvement of GABAA receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. / Egashira, Nobuaki; Hayakawa, Kazuhide; Osajima, Megumi; Mishima, Kenichi; Iwasaki, Katsunori; Oishi, Ryozo; Fujiwara, Michihiro.

In: Journal of Pharmacological Sciences, Vol. 105, No. 2, 20.11.2007, p. 211-214.

Research output: Contribution to journalArticle

Egashira, Nobuaki ; Hayakawa, Kazuhide ; Osajima, Megumi ; Mishima, Kenichi ; Iwasaki, Katsunori ; Oishi, Ryozo ; Fujiwara, Michihiro. / Involvement of GABAA receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. In: Journal of Pharmacological Sciences. 2007 ; Vol. 105, No. 2. pp. 211-214.
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AU - Fujiwara, Michihiro

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