Abstract
We investigated the involvement of γ-aminobutyric acidA (GABA A) receptors in the neuroprotective effect of γ- glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABAA-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABAA receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 211-214 |
| Number of pages | 4 |
| Journal | Journal of Pharmacological Sciences |
| Volume | 105 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Nov 20 2007 |
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All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Pharmacology
Cite this
Involvement of GABAA receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. / Egashira, Nobuaki; Hayakawa, Kazuhide; Osajima, Megumi; Mishima, Kenichi; Iwasaki, Katsunori; Oishi, Ryozo; Fujiwara, Michihiro.
In: Journal of Pharmacological Sciences, Vol. 105, No. 2, 20.11.2007, p. 211-214.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Involvement of GABAA receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice
AU - Egashira, Nobuaki
AU - Hayakawa, Kazuhide
AU - Osajima, Megumi
AU - Mishima, Kenichi
AU - Iwasaki, Katsunori
AU - Oishi, Ryozo
AU - Fujiwara, Michihiro
PY - 2007/11/20
Y1 - 2007/11/20
N2 - We investigated the involvement of γ-aminobutyric acidA (GABA A) receptors in the neuroprotective effect of γ- glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABAA-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABAA receptors.
AB - We investigated the involvement of γ-aminobutyric acidA (GABA A) receptors in the neuroprotective effect of γ- glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABAA-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABAA receptors.
UR - http://www.scopus.com/inward/record.url?scp=36148971162&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36148971162&partnerID=8YFLogxK
U2 - 10.1254/jphs.SCZ070901
DO - 10.1254/jphs.SCZ070901
M3 - Article
C2 - 17928735
AN - SCOPUS:36148971162
VL - 105
SP - 211
EP - 214
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8613
IS - 2
ER -