Involvement of insulin-like growth factor-1 in the effect of caloric restriction: Regulation of plasma adiponectin and leptin

Haruyoshi Yamaza, Toshimitsu Komatsu, Kazuo To, Hiroaki Toyama, Takuya Chiba, Yoshikazu Higami, Isao Shimokawa

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Insulin-like growth factor (IGF)-1 signaling might partly mediate effects of caloric restriction (CR), an experimental intervention for increasing longevity in mammals. The present study evaluated effects of recombinant human (rh)IGF-1 infusion on adipokine levels in CR and transgenic (Tg) dwarf rats with the reduced growth hormone-IGF-1 axis, which shared similar body weight and food intake. At 9 months of age, each rat received a continuous infusion of rhIGF-1 for 14 days, and rats received an injection of glucose after overnight fasting. Infusion of rhIGF-1 had metabolic effects in all rat groups although it did not affect insulin sensitivity in any of the groups. In addition, plasma adiponectin was decreased to the control group levels and plasma leptin was further reduced in CR and Tg rats. The similarity of phenotypes and adipokine responses to rhIGF-1 between CR and Tg rats supports a role for reduced IGF-1 signaling in the CR effect.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume62
Issue number1
DOIs
Publication statusPublished - Jan 1 2007

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Caloric Restriction
Adiponectin
Somatomedins
Leptin
Transgenic Rats
Adipokines
Growth Hormone
Insulin Resistance
Mammals
Fasting
Eating
Body Weight
Phenotype
Glucose
Control Groups
Injections

All Science Journal Classification (ASJC) codes

  • Ageing
  • Geriatrics and Gerontology

Cite this

Involvement of insulin-like growth factor-1 in the effect of caloric restriction : Regulation of plasma adiponectin and leptin. / Yamaza, Haruyoshi; Komatsu, Toshimitsu; To, Kazuo; Toyama, Hiroaki; Chiba, Takuya; Higami, Yoshikazu; Shimokawa, Isao.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 62, No. 1, 01.01.2007, p. 27-33.

Research output: Contribution to journalArticle

Yamaza, Haruyoshi ; Komatsu, Toshimitsu ; To, Kazuo ; Toyama, Hiroaki ; Chiba, Takuya ; Higami, Yoshikazu ; Shimokawa, Isao. / Involvement of insulin-like growth factor-1 in the effect of caloric restriction : Regulation of plasma adiponectin and leptin. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2007 ; Vol. 62, No. 1. pp. 27-33.
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