TY - JOUR
T1 - Involvement of microglia in disturbed fear memory regulation
T2 - Possible microglial contribution to the pathophysiology of posttraumatic stress disorder
AU - Enomoto, Shingo
AU - Kato, Takahiro A.
N1 - Funding Information:
This work was partially supported by Grant-in-Aid for Scientific Research on (1) The Japan Agency for Medical Research and Development (AMED) (Syogaisya-Taisaku-Sogo-Kenkyu-Kaihatsu-Jigyo ( JP17dk0307047 & JP20dk0307075 ), and Yugo-No ( JP20dm0107095 )), (2) Innovative Areas “Will-Dynamics” of The Ministry of Education, Culture, Sports, Science, and Technology, Japan ( JP16H06403 ), (3) KAKENHI - the Japan Society for the Promotion of Science ( JP26713039 , JP15K15431 , JP16H03741 , & JP18H04042 ), and (4) SENSHIN Medical Research Foundation . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would like to thank Editage ( www.editage.com ) for English language editing.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/1
Y1 - 2021/1
N2 - Microglia, immune cells in the brain, play a crucial role in brain inflammation and synaptic plasticity by releasing inflammatory mediators and neurotrophic factors as well as, phagocytosing synaptic elements. Recent studies have shown peripheral inflammation, immune alteration in the brain are associated with post-traumatic stress disorder (PTSD) in humans. Several preclinical studies using Pavlovian fear conditioning have suggested that microglia are involved in fear memory dysregulation and altered fear neuronal networks. Microglial priming resulting from previous stressful experiences may also have an effect. This review will introduce the current knowledge of microglial contribution to disturbed fear memory regulation, a fundamental feature of PTSD.
AB - Microglia, immune cells in the brain, play a crucial role in brain inflammation and synaptic plasticity by releasing inflammatory mediators and neurotrophic factors as well as, phagocytosing synaptic elements. Recent studies have shown peripheral inflammation, immune alteration in the brain are associated with post-traumatic stress disorder (PTSD) in humans. Several preclinical studies using Pavlovian fear conditioning have suggested that microglia are involved in fear memory dysregulation and altered fear neuronal networks. Microglial priming resulting from previous stressful experiences may also have an effect. This review will introduce the current knowledge of microglial contribution to disturbed fear memory regulation, a fundamental feature of PTSD.
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U2 - 10.1016/j.neuint.2020.104921
DO - 10.1016/j.neuint.2020.104921
M3 - Article
C2 - 33232758
AN - SCOPUS:85096847960
SN - 0197-0186
VL - 142
JO - Neurochemistry International
JF - Neurochemistry International
M1 - 104921
ER -