Involvement of (n-6) essential fatty acids and prostaglandins in liver lipid accumulation in Japanese quail

Atsushi Murai, Mitsuhiro Furuse, Jun Ichi Okumura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective - To investigate the involvement of (n-6) essential fatty acids, such as linoleic acid [18:2(n-6)] or γ-linolenic acid [18:3(n-6)], and of prostaglandins on liver lipid accumulation in Japanese quail. Design - Effects of graded amounts of aspirin, which inhibits prostaglandin synthesis, on liver weight were determined in experiment 1. Experiment 2 was designed to clarify the effect of dietary essential fatty acid sources and inhibition of prostaglandin synthesis on the liver fat and fatty acid profile. Animals - Female Japanese quail. Procedure - In experiment 1, from 1 to 3 weeks of age, birds were fed ad libitum the essential fatty acids-free or linoleic acid-adequate (2%) diets with graded amounts of aspirin (0, 0.1, 0.2, and 0.4%). In experiment 2, from 1 to 4 weeks of age, birds were fed the same amount of essential fatty acids-free, linoleic acid-adequate, or γ-linolenic acid (0.4%) diets with (0.2%) or without aspirin. Results - In experiment 1, in groups given the essential fatty acids-free diet, liver weight increased with an increase in dietary aspirin concentration. In experiment 2, γ-linolenic acid completely prevented liver triacylglycerol and cholesterol accumulation induced by the essential fatty acids-free diet. Aspirin treatment significantly lowered plasma prostaglandin F(2α) concentration, but did not affect liver lipid concentrations. In groups fed the essential fatty acids-free diets, however, aspirin treatment increased liver weight and liver triacylglycerol concentration by 20 and 40%, respectively. Conclusions - γ-Linolenic acid or its metabolites, but not linoleic acid itself, are important factors in reducing fatty liver in Japanese quail with the essential fatty acids deficient condition.

Original languageEnglish
Pages (from-to)342-345
Number of pages4
JournalAmerican journal of veterinary research
Volume57
Issue number3
Publication statusPublished - Mar 1 1996
Externally publishedYes

Fingerprint

Coturnix
Essential Fatty Acids
omega-6 fatty acids
essential fatty acids
prostaglandins
Prostaglandins
aspirin
Aspirin
Lipids
liver
alpha-Linolenic Acid
Liver
Linoleic Acid
lipids
linolenic acid
linoleic acid
Diet
diet
Weights and Measures
Birds

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Involvement of (n-6) essential fatty acids and prostaglandins in liver lipid accumulation in Japanese quail. / Murai, Atsushi; Furuse, Mitsuhiro; Okumura, Jun Ichi.

In: American journal of veterinary research, Vol. 57, No. 3, 01.03.1996, p. 342-345.

Research output: Contribution to journalArticle

@article{51f96ab41b6a4824b08d65736eb3456d,
title = "Involvement of (n-6) essential fatty acids and prostaglandins in liver lipid accumulation in Japanese quail",
abstract = "Objective - To investigate the involvement of (n-6) essential fatty acids, such as linoleic acid [18:2(n-6)] or γ-linolenic acid [18:3(n-6)], and of prostaglandins on liver lipid accumulation in Japanese quail. Design - Effects of graded amounts of aspirin, which inhibits prostaglandin synthesis, on liver weight were determined in experiment 1. Experiment 2 was designed to clarify the effect of dietary essential fatty acid sources and inhibition of prostaglandin synthesis on the liver fat and fatty acid profile. Animals - Female Japanese quail. Procedure - In experiment 1, from 1 to 3 weeks of age, birds were fed ad libitum the essential fatty acids-free or linoleic acid-adequate (2{\%}) diets with graded amounts of aspirin (0, 0.1, 0.2, and 0.4{\%}). In experiment 2, from 1 to 4 weeks of age, birds were fed the same amount of essential fatty acids-free, linoleic acid-adequate, or γ-linolenic acid (0.4{\%}) diets with (0.2{\%}) or without aspirin. Results - In experiment 1, in groups given the essential fatty acids-free diet, liver weight increased with an increase in dietary aspirin concentration. In experiment 2, γ-linolenic acid completely prevented liver triacylglycerol and cholesterol accumulation induced by the essential fatty acids-free diet. Aspirin treatment significantly lowered plasma prostaglandin F(2α) concentration, but did not affect liver lipid concentrations. In groups fed the essential fatty acids-free diets, however, aspirin treatment increased liver weight and liver triacylglycerol concentration by 20 and 40{\%}, respectively. Conclusions - γ-Linolenic acid or its metabolites, but not linoleic acid itself, are important factors in reducing fatty liver in Japanese quail with the essential fatty acids deficient condition.",
author = "Atsushi Murai and Mitsuhiro Furuse and Okumura, {Jun Ichi}",
year = "1996",
month = "3",
day = "1",
language = "English",
volume = "57",
pages = "342--345",
journal = "American Journal of Veterinary Research",
issn = "0002-9645",
publisher = "American Veterinary Medical Association",
number = "3",

}

TY - JOUR

T1 - Involvement of (n-6) essential fatty acids and prostaglandins in liver lipid accumulation in Japanese quail

AU - Murai, Atsushi

AU - Furuse, Mitsuhiro

AU - Okumura, Jun Ichi

PY - 1996/3/1

Y1 - 1996/3/1

N2 - Objective - To investigate the involvement of (n-6) essential fatty acids, such as linoleic acid [18:2(n-6)] or γ-linolenic acid [18:3(n-6)], and of prostaglandins on liver lipid accumulation in Japanese quail. Design - Effects of graded amounts of aspirin, which inhibits prostaglandin synthesis, on liver weight were determined in experiment 1. Experiment 2 was designed to clarify the effect of dietary essential fatty acid sources and inhibition of prostaglandin synthesis on the liver fat and fatty acid profile. Animals - Female Japanese quail. Procedure - In experiment 1, from 1 to 3 weeks of age, birds were fed ad libitum the essential fatty acids-free or linoleic acid-adequate (2%) diets with graded amounts of aspirin (0, 0.1, 0.2, and 0.4%). In experiment 2, from 1 to 4 weeks of age, birds were fed the same amount of essential fatty acids-free, linoleic acid-adequate, or γ-linolenic acid (0.4%) diets with (0.2%) or without aspirin. Results - In experiment 1, in groups given the essential fatty acids-free diet, liver weight increased with an increase in dietary aspirin concentration. In experiment 2, γ-linolenic acid completely prevented liver triacylglycerol and cholesterol accumulation induced by the essential fatty acids-free diet. Aspirin treatment significantly lowered plasma prostaglandin F(2α) concentration, but did not affect liver lipid concentrations. In groups fed the essential fatty acids-free diets, however, aspirin treatment increased liver weight and liver triacylglycerol concentration by 20 and 40%, respectively. Conclusions - γ-Linolenic acid or its metabolites, but not linoleic acid itself, are important factors in reducing fatty liver in Japanese quail with the essential fatty acids deficient condition.

AB - Objective - To investigate the involvement of (n-6) essential fatty acids, such as linoleic acid [18:2(n-6)] or γ-linolenic acid [18:3(n-6)], and of prostaglandins on liver lipid accumulation in Japanese quail. Design - Effects of graded amounts of aspirin, which inhibits prostaglandin synthesis, on liver weight were determined in experiment 1. Experiment 2 was designed to clarify the effect of dietary essential fatty acid sources and inhibition of prostaglandin synthesis on the liver fat and fatty acid profile. Animals - Female Japanese quail. Procedure - In experiment 1, from 1 to 3 weeks of age, birds were fed ad libitum the essential fatty acids-free or linoleic acid-adequate (2%) diets with graded amounts of aspirin (0, 0.1, 0.2, and 0.4%). In experiment 2, from 1 to 4 weeks of age, birds were fed the same amount of essential fatty acids-free, linoleic acid-adequate, or γ-linolenic acid (0.4%) diets with (0.2%) or without aspirin. Results - In experiment 1, in groups given the essential fatty acids-free diet, liver weight increased with an increase in dietary aspirin concentration. In experiment 2, γ-linolenic acid completely prevented liver triacylglycerol and cholesterol accumulation induced by the essential fatty acids-free diet. Aspirin treatment significantly lowered plasma prostaglandin F(2α) concentration, but did not affect liver lipid concentrations. In groups fed the essential fatty acids-free diets, however, aspirin treatment increased liver weight and liver triacylglycerol concentration by 20 and 40%, respectively. Conclusions - γ-Linolenic acid or its metabolites, but not linoleic acid itself, are important factors in reducing fatty liver in Japanese quail with the essential fatty acids deficient condition.

UR - http://www.scopus.com/inward/record.url?scp=0030001852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030001852&partnerID=8YFLogxK

M3 - Article

C2 - 8669766

AN - SCOPUS:0030001852

VL - 57

SP - 342

EP - 345

JO - American Journal of Veterinary Research

JF - American Journal of Veterinary Research

SN - 0002-9645

IS - 3

ER -