Involvement of neuronal cell surface molecule B2 in the formation of retinal plexiform layers

Kunimasa Ohta, Shin Takagi, Hiroaki Asou, Hajime Fujisawa

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The B2 molecule is a 220 kd neuronal cell surface protein of Xenopus, recognized by monoclonal antibody B2 (MAb B2). Immunohistochemistry using MAb B2 revealed that the B2 molecule was expessed in both the inner and outer plexiform layers within the neural retina. During development of the neural retina, the B2 molecule first appeared at stages 35 36 in the newly formed plexiform layers. When embryonic eyes were cultured in the presence of anti-B2 antiserum (Fab fragments), the formation of the retinal plexiform layers was impeded. These data suggest that the cell surface molecule B2 plays a role in the development of retinal plexiform layers.

Original languageEnglish
Pages (from-to)151-161
Number of pages11
JournalNeuron
Volume9
Issue number1
DOIs
Publication statusPublished - Jul 1992

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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