Involvement of substance P, mast cells, TNF-α and ICAM-1 in the infiltration of inflammatory cells in human periapical granulomas

Hiroaki Kabashima, Kengo Nagata, Katsumasa Maeda, Tadahiko Iijima

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Substance P (SP), a potent proinflammatory peptide present in sensory neurons, is believed to be a major mediator of neurogenic inflammation. The aim of this study was to examine the localization and involvement of SP, mast cells and tumor necrosis factor-α (TNF-α)-positive cells in human periapical granulomas. Methods: Sections from seven periapical granulomas were stained using a variety of immunohistochemical methods. Results: SP-immunoreactive nerve fibers, mast cells and TNF-α-positive cells were found localized in the vicinity of blood vessels in all the samples of periapical granulomas. The vascular endothelial cells stained positively for E-selectin and intercellular adhesion molecule-1. SP, TNF-α-positive cells and E-selectin could not be detected in clinically healthy periodontal ligament, and served as a negative control. Conclusion: Our findings suggest that SP, mast cells, TNF-α-positive cells and E-selectin may modulate the pathogenesis of apical periodontitis and may be responsible for stimulating the formation of granuloma with the resorption of periapical bone.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalJournal of Oral Pathology and Medicine
Volume31
Issue number3
DOIs
Publication statusPublished - 2002

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Periapical Granuloma
Intercellular Adhesion Molecule-1
Substance P
Mast Cells
Tumor Necrosis Factor-alpha
E-Selectin
Periapical Periodontitis
Neurogenic Inflammation
Inflammation Mediators
Periodontal Ligament
Sensory Receptor Cells
Bone Resorption
Granuloma
Nerve Fibers
Blood Vessels
Endothelial Cells
Peptides

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Pathology and Forensic Medicine
  • Dentistry(all)

Cite this

Involvement of substance P, mast cells, TNF-α and ICAM-1 in the infiltration of inflammatory cells in human periapical granulomas. / Kabashima, Hiroaki; Nagata, Kengo; Maeda, Katsumasa; Iijima, Tadahiko.

In: Journal of Oral Pathology and Medicine, Vol. 31, No. 3, 2002, p. 175-180.

Research output: Contribution to journalArticle

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AU - Iijima, Tadahiko

PY - 2002

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N2 - Background: Substance P (SP), a potent proinflammatory peptide present in sensory neurons, is believed to be a major mediator of neurogenic inflammation. The aim of this study was to examine the localization and involvement of SP, mast cells and tumor necrosis factor-α (TNF-α)-positive cells in human periapical granulomas. Methods: Sections from seven periapical granulomas were stained using a variety of immunohistochemical methods. Results: SP-immunoreactive nerve fibers, mast cells and TNF-α-positive cells were found localized in the vicinity of blood vessels in all the samples of periapical granulomas. The vascular endothelial cells stained positively for E-selectin and intercellular adhesion molecule-1. SP, TNF-α-positive cells and E-selectin could not be detected in clinically healthy periodontal ligament, and served as a negative control. Conclusion: Our findings suggest that SP, mast cells, TNF-α-positive cells and E-selectin may modulate the pathogenesis of apical periodontitis and may be responsible for stimulating the formation of granuloma with the resorption of periapical bone.

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