TY - JOUR
T1 - Involvement of sulfatide in activation of protein kinase C by tumor promoters
AU - Fujiki, Hirota
AU - Yamashita, Katsumi
AU - Suganuma, Masami
AU - Horiuchi, Takahiko
AU - Taniguchi, Naoyuki
AU - Makita, Akira
N1 - Funding Information:
This work was supported in part by Grants-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, the Ministry of Health and Welfare of Japan, a Comprehensive IO-Year Strategy for Cancer Control from the Foundation for Promotion of Cancer Research, the Princess Takamatsu Cancer Research Fund, the Adult Disease Clinic Memorial Foundation and Nishi Cancer Research Fund of Japan. Katsumi Yamashita thanks the Foundation for Promotion of Cancer Research, Japan for support in work at the National Cancer Center Research Institute, Tokyo.
PY - 1986/7/16
Y1 - 1986/7/16
N2 - Sulfatide (cerebroside sulfate) activated protein kinase C to the same extent as phosphatidylserine did with the tumor promoters, 12-0-tetradecanoylphorbol-13-acetate (TPA), teleocidin and debromo-aplysiatoxin. Sulfatide and phosphatidylserine both induced specific binding of [3H]TPA to protein kinase C, although the ratios of specific to non-specific [3H]TPA binding to protein kinase C with the two were not the same. It is concluded that sulfatide is involved in activation of protein kinase C by tumor promoters in a slightly different way from phosphatidylserine.
AB - Sulfatide (cerebroside sulfate) activated protein kinase C to the same extent as phosphatidylserine did with the tumor promoters, 12-0-tetradecanoylphorbol-13-acetate (TPA), teleocidin and debromo-aplysiatoxin. Sulfatide and phosphatidylserine both induced specific binding of [3H]TPA to protein kinase C, although the ratios of specific to non-specific [3H]TPA binding to protein kinase C with the two were not the same. It is concluded that sulfatide is involved in activation of protein kinase C by tumor promoters in a slightly different way from phosphatidylserine.
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U2 - 10.1016/0006-291X(86)90259-7
DO - 10.1016/0006-291X(86)90259-7
M3 - Article
C2 - 3091011
AN - SCOPUS:0022535483
VL - 138
SP - 153
EP - 158
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -