TY - JOUR
T1 - Involvement of sulfatide in activation of protein kinase C by tumor promoters
AU - Fujiki, Hirota
AU - Yamashita, Katsumi
AU - Suganuma, Masami
AU - Horiuchi, Takahiko
AU - Taniguchi, Naoyuki
AU - Makita, Akira
PY - 1986/7/16
Y1 - 1986/7/16
N2 - Sulfatide (cerebroside sulfate) activated protein kinase C to the same extent as phosphatidylserine did with the tumor promoters, 12-0-tetradecanoylphorbol-13-acetate (TPA), teleocidin and debromo-aplysiatoxin. Sulfatide and phosphatidylserine both induced specific binding of [3H]TPA to protein kinase C, although the ratios of specific to non-specific [3H]TPA binding to protein kinase C with the two were not the same. It is concluded that sulfatide is involved in activation of protein kinase C by tumor promoters in a slightly different way from phosphatidylserine.
AB - Sulfatide (cerebroside sulfate) activated protein kinase C to the same extent as phosphatidylserine did with the tumor promoters, 12-0-tetradecanoylphorbol-13-acetate (TPA), teleocidin and debromo-aplysiatoxin. Sulfatide and phosphatidylserine both induced specific binding of [3H]TPA to protein kinase C, although the ratios of specific to non-specific [3H]TPA binding to protein kinase C with the two were not the same. It is concluded that sulfatide is involved in activation of protein kinase C by tumor promoters in a slightly different way from phosphatidylserine.
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U2 - 10.1016/0006-291X(86)90259-7
DO - 10.1016/0006-291X(86)90259-7
M3 - Article
C2 - 3091011
AN - SCOPUS:0022535483
VL - 138
SP - 153
EP - 158
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -