Involvement of sulfatide in activation of protein kinase C by tumor promoters

Hirota Fujiki; Katsumi Yamashita; Masami Suganuma; Takahiko Horiuchi; Naoyuki Taniguchi; Akira Makita

doi:10.1016/0006-291X(86)90259-7

Involvement of sulfatide in activation of protein kinase C by tumor promoters

Hirota Fujiki, Katsumi Yamashita, Masami Suganuma, Takahiko Horiuchi, Naoyuki Taniguchi, Akira Makita

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Sulfatide (cerebroside sulfate) activated protein kinase C to the same extent as phosphatidylserine did with the tumor promoters, 12-0-tetradecanoylphorbol-13-acetate (TPA), teleocidin and debromo-aplysiatoxin. Sulfatide and phosphatidylserine both induced specific binding of [³H]TPA to protein kinase C, although the ratios of specific to non-specific [³H]TPA binding to protein kinase C with the two were not the same. It is concluded that sulfatide is involved in activation of protein kinase C by tumor promoters in a slightly different way from phosphatidylserine.

Original language	English
Pages (from-to)	153-158
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	138
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(86)90259-7
Publication status	Published - Jul 16 1986
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "Sulfatide (cerebroside sulfate) activated protein kinase C to the same extent as phosphatidylserine did with the tumor promoters, 12-0-tetradecanoylphorbol-13-acetate (TPA), teleocidin and debromo-aplysiatoxin. Sulfatide and phosphatidylserine both induced specific binding of [3H]TPA to protein kinase C, although the ratios of specific to non-specific [3H]TPA binding to protein kinase C with the two were not the same. It is concluded that sulfatide is involved in activation of protein kinase C by tumor promoters in a slightly different way from phosphatidylserine.",

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AU - Fujiki, Hirota

AU - Yamashita, Katsumi

AU - Suganuma, Masami

AU - Horiuchi, Takahiko

AU - Taniguchi, Naoyuki

AU - Makita, Akira

PY - 1986/7/16

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AB - Sulfatide (cerebroside sulfate) activated protein kinase C to the same extent as phosphatidylserine did with the tumor promoters, 12-0-tetradecanoylphorbol-13-acetate (TPA), teleocidin and debromo-aplysiatoxin. Sulfatide and phosphatidylserine both induced specific binding of [3H]TPA to protein kinase C, although the ratios of specific to non-specific [3H]TPA binding to protein kinase C with the two were not the same. It is concluded that sulfatide is involved in activation of protein kinase C by tumor promoters in a slightly different way from phosphatidylserine.

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