Involvement of sulfatide in activation of protein kinase C by tumor promoters

Hirota Fujiki, Katsumi Yamashita, Masami Suganuma, Takahiko Horiuchi, Naoyuki Taniguchi, Akira Makita

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Sulfatide (cerebroside sulfate) activated protein kinase C to the same extent as phosphatidylserine did with the tumor promoters, 12-0-tetradecanoylphorbol-13-acetate (TPA), teleocidin and debromo-aplysiatoxin. Sulfatide and phosphatidylserine both induced specific binding of [3H]TPA to protein kinase C, although the ratios of specific to non-specific [3H]TPA binding to protein kinase C with the two were not the same. It is concluded that sulfatide is involved in activation of protein kinase C by tumor promoters in a slightly different way from phosphatidylserine.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume138
Issue number1
DOIs
Publication statusPublished - Jul 16 1986
Externally publishedYes

Fingerprint

Sulfoglycosphingolipids
Carcinogens
Protein Kinase C
Phosphatidylserines
Tetradecanoylphorbol Acetate
Chemical activation
Acetates
Carrier Proteins

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Involvement of sulfatide in activation of protein kinase C by tumor promoters. / Fujiki, Hirota; Yamashita, Katsumi; Suganuma, Masami; Horiuchi, Takahiko; Taniguchi, Naoyuki; Makita, Akira.

In: Biochemical and Biophysical Research Communications, Vol. 138, No. 1, 16.07.1986, p. 153-158.

Research output: Contribution to journalArticle

Fujiki, Hirota ; Yamashita, Katsumi ; Suganuma, Masami ; Horiuchi, Takahiko ; Taniguchi, Naoyuki ; Makita, Akira. / Involvement of sulfatide in activation of protein kinase C by tumor promoters. In: Biochemical and Biophysical Research Communications. 1986 ; Vol. 138, No. 1. pp. 153-158.
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