Involvement of sulfatide in activation of protein kinase C by tumor promoters

Hirota Fujiki, Katsumi Yamashita, Masami Suganuma, Takahiko Horiuchi, Naoyuki Taniguchi, Akira Makita

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Sulfatide (cerebroside sulfate) activated protein kinase C to the same extent as phosphatidylserine did with the tumor promoters, 12-0-tetradecanoylphorbol-13-acetate (TPA), teleocidin and debromo-aplysiatoxin. Sulfatide and phosphatidylserine both induced specific binding of [3H]TPA to protein kinase C, although the ratios of specific to non-specific [3H]TPA binding to protein kinase C with the two were not the same. It is concluded that sulfatide is involved in activation of protein kinase C by tumor promoters in a slightly different way from phosphatidylserine.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume138
Issue number1
DOIs
Publication statusPublished - Jul 16 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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