Involvement of the medial amygdaloid nucleus in the action of imipramine in rats subjected to the forced swimming test

Takao Shimazoe, Shigenobu Shibata, Shin Ichi Yatsugi, Showa Ueki

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A forced swimming test proposed by Porsolt1) is a useful method for screening antidepressants. To evaluate drug effects more objectively, vibration of the walls of a water tank caused by the escape behavior of the rat was recorded. Imipramine (IMI) increased the number of vibration and this effect was observed in the medial amygdala lesioned rat but not in the central or basolateral amygdala le-sioned rat. The present result suggests that the medial amygdala is an important site of action of IMI.

Original languageEnglish
Pages (from-to)137-139
Number of pages3
Journaljournal of pharmacobio-dynamics
Issue number2
Publication statusPublished - Feb 1 1988


All Science Journal Classification (ASJC) codes

  • Pharmacology

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