Involvement of the medial amygdaloid nucleus in the action of imipramine in rats subjected to the forced swimming test

Takao Shimazoe; Shigenobu Shibata; Shin Ichi Yatsugi; Showa Ueki

doi:10.1248/bpb1978.11.137

Involvement of the medial amygdaloid nucleus in the action of imipramine in rats subjected to the forced swimming test

Takao Shimazoe, Shigenobu Shibata, Shin Ichi Yatsugi, Showa Ueki

Pharmaceutical Health Care and Sciences Faculty

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A forced swimming test proposed by Porsolt¹⁾ is a useful method for screening antidepressants. To evaluate drug effects more objectively, vibration of the walls of a water tank caused by the escape behavior of the rat was recorded. Imipramine (IMI) increased the number of vibration and this effect was observed in the medial amygdala lesioned rat but not in the central or basolateral amygdala le-sioned rat. The present result suggests that the medial amygdala is an important site of action of IMI.

Original language	English
Pages (from-to)	137-139
Number of pages	3
Journal	journal of pharmacobio-dynamics
Volume	11
Issue number	2
DOIs	https://doi.org/10.1248/bpb1978.11.137
Publication status	Published - Feb 1 1988

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1248/bpb1978.11.137

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Involvement of the medial amygdaloid nucleus in the action of imipramine in rats subjected to the forced swimming test

Abstract

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