Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior: Comparison with paroxetine

Nobuaki Egashira, Satoko Harada, Ryoko Okuno, Michihiko Matsushita, Ryoji Nishimura, Kenichi Mishima, Katsunori Iwasaki, Kensuke Orito, Michihiro Fujiwara

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

In the present study, we examined the involvement of the sigma1 receptor in the inhibitory effect of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine, compared with that of paroxetine, on marble-burying behavior, which is an animal model of obsessive-compulsive disorder. Sigma1 receptor agonists (+)-SKF 10047 and PRE-084 significantly inhibited marble-burying behavior. Sigma receptor antagonist BD 1047 and selective sigma1 receptor antagonist BD 1063 significantly attenuated the inhibition of marble-burying behavior by fluvoxamine. In contrast, selective sigma2 receptor antagonist SM-21 failed to affect the inhibition of marble-burying behavior by fluvoxamine. On the other hand, BD 1047 and BD 1063 had no effect on the inhibition of marble-burying behavior by paroxetine. These observations show that activation of the sigma1 receptor is a necessary component in the inhibitory effect of fluvoxamine on marble-burying behavior, and that the mechanism of its action is clearly different from that of paroxetine.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalEuropean Journal of Pharmacology
Volume563
Issue number1-3
DOIs
Publication statusPublished - Jun 1 2007

All Science Journal Classification (ASJC) codes

  • Pharmacology

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