Ionic liquid-in-oil microemulsions as potential carriers for the transdermal delivery of Methotrexate

Hiromu Yoshiura, Miki Tamura, Makoto Aso, Noriho Kamiya, Masahiro Goto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Ionic liquid-in-oil (IL/o) microemulsion (ME) techniques have been employed to increase the solubility of sparingly soluble drugs and enhance the extent of their topical and transdermal delivery. Methotrexate (MTX) has been used as a model drug in the current study. The size and size distributions of the ME droplets in the presence and in the absence of MTX were determined by dynamic light scattering analysis. The mean droplet diameter of the ME droplets containing 4 mg/mL of MTX was less than 20 nm, and smaller than the corresponding value observed in the absence of MTX. MTX was incorporated into IL droplets as well as other formulations and its permeation across Yucatan micropig (YMP) porcine skin evaluated. The use of IL/o ME has been shown to dramatically increase MTX administration. The results obtained in this study reveal the versatility of IL/o MEs as efficient drug delivery systems for sparingly soluble drugs.

Original languageEnglish
Pages (from-to)794-796
Number of pages3
JournalJOURNAL OF CHEMICAL ENGINEERING OF JAPAN
Volume46
Issue number11
DOIs
Publication statusPublished - Nov 27 2013

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Ionic Liquids
Microemulsions
Ionic liquids
Methotrexate
Oils
Dynamic light scattering
Permeation
Pharmaceutical Preparations
Skin
Solubility

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Ionic liquid-in-oil microemulsions as potential carriers for the transdermal delivery of Methotrexate. / Yoshiura, Hiromu; Tamura, Miki; Aso, Makoto; Kamiya, Noriho; Goto, Masahiro.

In: JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, Vol. 46, No. 11, 27.11.2013, p. 794-796.

Research output: Contribution to journalArticle

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