Irciniasulfonic acid B (1) was obtained from a marine sponge, Ircinia sp., together with a known multi-drug resistance modulator irciniasulfonic acid (2). Spectroscopic and chemical analyses revealed structure consisting of common unsaturated fatty acids, a novel unsaturated branched fatty acid, and a taurine. Final separation of irciniasulfonic acid B (1) was achieved with its methylated derivatives. Irciniasulfonic acid B (1) reversed the multi-drug resistance in the same way as irciniasulfonic acid.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry