Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents

A protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction

Shintaro Kawamura, Tatsuya Kawabata, Kentaro Ishizuka, Masaharu Nakamura

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Non-protected halohydrins are cross-coupled with aryl aluminium reagents to produce aryl alkanols in the presence of the iron-bisphosphine catalysts. Remarkable reaction rate enhancement and diastereoinduction are realized by the in situ generated aluminium alkoxides, offering a new method for the reactivity and selectivity control of the iron-catalysed cross-coupling reaction.

Original languageEnglish
Pages (from-to)9376-9378
Number of pages3
JournalChemical Communications
Volume48
Issue number75
DOIs
Publication statusPublished - Sep 28 2012

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Aluminum
Iron
Reaction rates
Catalysts

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents : A protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction. / Kawamura, Shintaro; Kawabata, Tatsuya; Ishizuka, Kentaro; Nakamura, Masaharu.

In: Chemical Communications, Vol. 48, No. 75, 28.09.2012, p. 9376-9378.

Research output: Contribution to journalArticle

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