Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: A protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction

Shintaro Kawamura, Tatsuya Kawabata, Kentaro Ishizuka, Masaharu Nakamura

    Research output: Contribution to journalArticlepeer-review

    37 Citations (Scopus)

    Abstract

    Non-protected halohydrins are cross-coupled with aryl aluminium reagents to produce aryl alkanols in the presence of the iron–bisphosphine catalysts. Remarkable reaction rate enhancement and diastereoinduction are realized by the in situ generated aluminium alkoxides, offering a new method for the reactivity and selectivity control of the iron-catalysed cross-coupling reaction. 2012

    Original languageEnglish
    Pages (from-to)9376-9378
    Number of pages3
    JournalChemical Communications
    Volume48
    Issue number75
    DOIs
    Publication statusPublished - Aug 22 2012

    All Science Journal Classification (ASJC) codes

    • Catalysis
    • Electronic, Optical and Magnetic Materials
    • Ceramics and Composites
    • Chemistry(all)
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

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