Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: A protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction

Shintaro Kawamura; Tatsuya Kawabata; Kentaro Ishizuka; Masaharu Nakamura

doi:10.1039/c2cc34185a

Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: A protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction

Shintaro Kawamura, Tatsuya Kawabata, Kentaro Ishizuka, Masaharu Nakamura

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Non-protected halohydrins are cross-coupled with aryl aluminium reagents to produce aryl alkanols in the presence of the iron–bisphosphine catalysts. Remarkable reaction rate enhancement and diastereoinduction are realized by the in situ generated aluminium alkoxides, offering a new method for the reactivity and selectivity control of the iron-catalysed cross-coupling reaction. 2012

Original language	English
Pages (from-to)	9376-9378
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	75
DOIs	https://doi.org/10.1039/c2cc34185a
Publication status	Published - Aug 22 2012

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc34185a

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Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: A protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction. / Kawamura, Shintaro; Kawabata, Tatsuya; Ishizuka, Kentaro et al.
In: Chemical Communications, Vol. 48, No. 75, 22.08.2012, p. 9376-9378.

Research output: Contribution to journal › Article › peer-review

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Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: A protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction

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