Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: A protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction

Shintaro Kawamura, Tatsuya Kawabata, Kentaro Ishizuka, Masaharu Nakamura

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Non-protected halohydrins are cross-coupled with aryl aluminium reagents to produce aryl alkanols in the presence of the iron–bisphosphine catalysts. Remarkable reaction rate enhancement and diastereoinduction are realized by the in situ generated aluminium alkoxides, offering a new method for the reactivity and selectivity control of the iron-catalysed cross-coupling reaction. 2012

Original languageEnglish
Pages (from-to)9376-9378
Number of pages3
JournalChemical Communications
Volume48
Issue number75
DOIs
Publication statusPublished - Aug 22 2012

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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