@article{45cb4531048c433588adfdcac72e89e7,
title = "Iron-rich Kupffer cells exhibit phenotypic changes during the development of liver fibrosis in NASH",
abstract = "Biological",
author = "Yohei Kanamori and Miyako Tanaka and Michiko Itoh and Kozue Ochi and Ayaka Ito and Isao Hidaka and Isao Sakaida and Yoshihiro Ogawa and Takayoshi Suganami",
note = "Funding Information: We thank Dr. Joel K. Elmquist (University of Texas Southwestern Medical Center) for his generous gift of MC4R-KO mice. We also thank Dr. Takahisa Nakamura (Cincinnati Children's Hospital) and the members of the Suganami laboratory for their helpful discussions, Dr. Tasuku Hirayama (Gifu Pharmaceutical University) and Dr. Yasumitsu Ogra (Chiba University) for technical advice, and Center for Animal Research and Education (CARE), Nagoya University for support on animal experiments. This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan ( 20H03447 , 20H05503 , and 20H04944 to T.S.; 18K08508 to M.T.; and 19K16539 and 18J00710 to Y.K.) and Japan Agency for Medical Research and Development ( CREST ) ( JP20gm1210009s0102 and 20fk0210082s0101 to T.S.). This study was also supported by research grants from The Hori Sciences and Arts Foundation , Smoking Research Foundation , Daiko Foundation (T.S.), Mochida Memorial Foundation for Medical and Pharmaceutical Research (Y.K.), and Takeda Science Foundation (T.S. and Y.K.). Funding Information: We thank Dr. Joel K. Elmquist (University of Texas Southwestern Medical Center) for his generous gift of MC4R-KO mice. We also thank Dr. Takahisa Nakamura (Cincinnati Children's Hospital) and the members of the Suganami laboratory for their helpful discussions, Dr. Tasuku Hirayama (Gifu Pharmaceutical University) and Dr. Yasumitsu Ogra (Chiba University) for technical advice, and Center for Animal Research and Education (CARE), Nagoya University for support on animal experiments. This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (20H03447, 20H05503, and 20H04944 to T.S.; 18K08508 to M.T.; and 19K16539 and 18J00710 to Y.K.) and Japan Agency for Medical Research and Development (CREST) (JP20gm1210009s0102 and 20fk0210082s0101 to T.S.). This study was also supported by research grants from The Hori Sciences and Arts Foundation, Smoking Research Foundation, Daiko Foundation (T.S.), Mochida Memorial Foundation for Medical and Pharmaceutical Research (Y.K.), and Takeda Science Foundation (T.S. and Y.K.). Y.K. M.T. and T.S. designed the experiments. Y.K. M.T. M.I. and K.O. performed experiments. Y.K. M.T. M.I. and T.S. interpreted the data. I.H. and I.S. provided human samples. A.I. and Y.O. contributed to critical discussion. Y.K. M.T. and T.S. drafted and edited the manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2021",
month = feb,
day = "19",
doi = "10.1016/j.isci.2020.102032",
language = "English",
volume = "24",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "2",
}