Irreversible electroporation: Medical application of intense electric pulses for sustainable health

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Irreversible electroporation (IRE) is a promising method for the ablation of tumors using intense electric pulses. Because the mechanism of IRE is based on the breaking of the cytoplasmic membrane, only the cells are necrotized non-Thermally without causing damage to the extracellular matrix when pulse settings are optimized to avoid Joule heating. In IRE therapy, a train of electric pulses of a few kilovolts is applied to the targeted tissue via a pair of electrodes. To definitely ablate the tissue and minimize the temperature rise during the application of pulses, determination of the adequate settings of the pulsesand electrode configuration prior to the therapy are important. Studies from the engineering perspective are therefore highly helpful for the successful use of IRE. In the current study, the authors' work associated with IRE will be introduced, including a 3D numerical simulation for the estimation of the electric field and temperature distribution around the electrodes, IRE experiment with a 3D cell culture model, and evaluation of cell destruction and thermal injury.

Original languageEnglish
Title of host publicationSustainable Energy and Advanced Materials
Subtitle of host publicationProceeding of the 4th International Conference and Exhibition on Sustainable Energy and Advanced Materials 2015, ICE-SEAM 2015
PublisherAmerican Institute of Physics Inc.
Volume1717
ISBN (Electronic)9780735413658
DOIs
Publication statusPublished - Mar 29 2016
Event4th International Conference and Exhibition on Sustainable Energy and Advanced Materials 2015, ICE-SEAM 2015 - Solo, Indonesia
Duration: Nov 11 2015Nov 12 2015

Other

Other4th International Conference and Exhibition on Sustainable Energy and Advanced Materials 2015, ICE-SEAM 2015
CountryIndonesia
CitySolo
Period11/11/1511/12/15

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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    Kurata, K., & Takamatsu, H. (2016). Irreversible electroporation: Medical application of intense electric pulses for sustainable health. In Sustainable Energy and Advanced Materials: Proceeding of the 4th International Conference and Exhibition on Sustainable Energy and Advanced Materials 2015, ICE-SEAM 2015 (Vol. 1717). [4943424] American Institute of Physics Inc.. https://doi.org/10.1063/1.4943424