Is home blood pressure variability itself an interventional target beyond lowering mean home blood pressure during anti-hypertensive treatment

Satoshi Hoshide, Yuichiro Yano, motohiro shimizu, Kazuo Eguchi, Joji Ishikawa, Kazuomi Kario

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It is unknown whether home blood pressure (BP) variability reduction is associated with target organ damage (TOD) protection independently of home mean BP reduction. We enrolled 310 hypertensive patients whose systolic BP (SBP) at home was over 135mmHg. The subjects measured their BP in the morning and evening for 7 days. In addition, we measured urinary albumin excretion (UAE) as a marker of TOD before and after 6 months of candesartan treatment (+thiazidediuretics). At baseline, UAE was associated with average home SBP (r=0.24, P<0.001), the s.d. of home SBP (r=0.15, P=0.011), and the maximum home SBP (r=0.27, P<0.001). During the intervention, significant reductions were found in average home SBP (146±13 vs. 132±12mmHg, P<0.001), s.d. of home SBP (12.9±4.8 vs. 11.8±4.4mmHg, P<0.001), and maximum home SBP (172.5±18.0 vs. 155.9±17.5mmHg, P<0.001). UAE levels were significantly reduced after 6months of therapy compared with baseline (18.9 vs. 12.1 mgg-1 Cre, P<0.001). In multiple regression analysis, the treatment-induced reduction in UAE was significantly associated with that of average home BP (P=0.003) but was not associated with that of s.d. of home SBP or that of maximum home SBP. Home BP variability is not itself an interventional target beyond lowering mean home BP during anti-hypertensive treatment.

Original languageEnglish
Pages (from-to)862-866
Number of pages5
JournalHypertension Research
Issue number8
Publication statusPublished - Aug 1 2012


All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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