Is the Cessation of Blood Flow Faster than the Polymerization of an n-Butyl Cyanoacrylate–Lipiodol Mixture? An In Vitro Phantom Study

Natsuko Hayashi, Yoshito Takeuchi, Hiroshi Miura, Yusuke Arima, Mitsuaki Toda, Toshiyuki Okamoto, Shunsuke Asai, Koji Sakai, Tatsuya Hirota, Kei Yamada

Research output: Contribution to journalArticle


Purpose: To compare the polymerization time of n-butyl cyanoacrylate (NBCA) and lipiodol mixture in a static model and a pulsating flow model simulating embolization procedure of small caliber arteries. Materials and Methods: The polymerization time of NBCA–lipiodol mixture was measured by the morphological changes of a glue droplet in a petri dish. For the flow model, we used a 2-mm-inner-diameter polyvinyl alcohol tube connected to a pulsation pump. Bovine serum was supplied from the pump and circulated into the system at 30 ml/min and 60 bpm. A 0.64-mm-inner-diameter silicon microcatheter was inserted into this system, and then, 0.5 ml of glue was injected into the tube. The flow cessation time was defined as the time it took to stop the serum draining from the end of the tube. Six samples of 100, 66, 50, 40, 33, and 20 vol% NBCA were assessed. Results: The median polymerization times for each concentration were 0.12, 3.72, 12.30, 27.41, 57.68, and 63.67 s, respectively. The median flow cessation times were 0.28, 0.78, 1.43, 3.75, 4.50, and 9.29 s, respectively. The flow cessation time was significantly shorter than the polymerization time for all samples except for 100 vol% cyanoacrylate (p < 0.05). Conclusion: The flow cessation time of cyanoacrylate glue was significantly shorter than the polymerization time in an in vitro experiment. The injected glue possibly stops the blood flow before the completion of polymerization in the vascular system.

Original languageEnglish
Pages (from-to)630-635
Number of pages6
JournalCardioVascular and Interventional Radiology
Issue number4
Publication statusAccepted/In press - Jan 1 2019


All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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