Ischemic brain metabolism in patients with chronic cerebrovascular disease

Increased oxygen extraction fraction and cerebrospinal fluid lactate

Setsuro Ibayashi, Katsumi Irie, Jiro Kitayama, Tetsuhiko Nagao, Takanari Kitazono, Masatoshi Fujishima

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The aim of the present study is to elucidate the existence of chronically ischemic metabolism concomitant with misery perfusion of the brain in patients with chronic cerebrovascular disease. For this purpose, we measured cerebral blood flow (CBF) and oxygen metabolism by positron emission tomography (PET) and also determined cerebrospinal fluid (CSF) lactate as an indicator of the ischemic brain metabolism. Twenty-eight patients with chronic ischemic stroke and transient ischemic attack (TIA), who had angiographically occlusive (n = 11), stenotic (n = 10), and nonstenotic changes (n = 7) of the carotid artery and/or the intracranial major artery, were selected for this study. CBF, oxygen extraction fraction (OEF), cerebral metabolic rate for oxygen (CMRO2), and cerebral blood volume (CBV) were determined by PET, and CSF lactate and pyruvate were determined by enzymatic method in the patients with various grades of stenotic changes of the carotid artery. There were no significant differences in PET parameters and CSF variables among the groups of the occlusive, stenotic, and nonstenotic carotid artery. However, CSF lactate was correlated negatively with mean bilateral hemispheric (m)CBF (R2 = 0.229, P < .01), positively with mOEF (R2 = 0.278, P < .005) and more highly with mCMRO2/CBF (absolute extraction of oxygen content to the brain) (R2 = 0.473, P < .0001) in all patients. There was no correlation between CSF lactate and mCMRO2 or mCBV. None of the cases in the nonstenotic group showed mOEF greater than 0.45, or mCMRO2/CBF greater than 7.9 vol%, while 80% of the cases in the stenotic group and 82% of the cases in the occlusive group showed mOEF and mCMRO2/CBF exceeding the above-mentioned values, respectively. The present findings, that increased mOEF and mCMRO2/CBF were significantly correlated with increased CSF lactate, indicate the brain to be in a metabolically ischemic state or increased anaerobic glycolysis with oxygen metabolism maintained in patients with chronic ischemic stroke.

Original languageEnglish
Pages (from-to)166-171
Number of pages6
JournalJournal of Stroke and Cerebrovascular Diseases
Volume9
Issue number4
DOIs
Publication statusPublished - Jan 1 2000

Fingerprint

Cerebrovascular Circulation
Cerebrovascular Disorders
Cerebrospinal Fluid
Lactic Acid
Chronic Disease
Oxygen
Brain
Carotid Arteries
Positron-Emission Tomography
Stroke
Transient Ischemic Attack
Glycolysis
Pyruvic Acid
Arteries
Perfusion

All Science Journal Classification (ASJC) codes

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Ischemic brain metabolism in patients with chronic cerebrovascular disease : Increased oxygen extraction fraction and cerebrospinal fluid lactate. / Ibayashi, Setsuro; Irie, Katsumi; Kitayama, Jiro; Nagao, Tetsuhiko; Kitazono, Takanari; Fujishima, Masatoshi.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 9, No. 4, 01.01.2000, p. 166-171.

Research output: Contribution to journalArticle

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AU - Ibayashi, Setsuro

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AU - Nagao, Tetsuhiko

AU - Kitazono, Takanari

AU - Fujishima, Masatoshi

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