Isoflavones suppress the expression of the FcεRI high-affinity immunoglobulin e receptor independent of the estrogen receptor

Shuya Yamashita, Shuntaro Tsukamoto, Motofumi Kumazoe, Yoon Hee Kim, Koji Yamada, Hirofumi Tachibana

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Isoflavones found in soybeans and soy products possess clinically relevant properties. However, the anti-allergic effect of isoflavones has been poorly studied. We examined the effects of isoflavones, genistein, daidzein, and equol, on the expression of the high-affinity immunoglobulin E (IgE) receptor, FcεRI, which plays a central role in IgE-mediated allergic response. Flow cytometric analysis showed that all of these isoflavones reduced the cell surface expression of FcεRI on mouse bone-marrow-derived mast cells and human basophilic KU812 cells. All isoflavones decreased the levels of the FcεRIα mRNA in the cells. Genistein reduced the mRNA expression of the β chain, and daidzein and equol downregulated that of the γ chain. The suppressive effects of isoflavones on FcεRI expression were unaffected by ICI 182,780, an estrogen receptor antagonist, suggesting that these effects were independent of estrogen receptors.

Original languageEnglish
Pages (from-to)8379-8385
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume60
Issue number34
DOIs
Publication statusPublished - Aug 29 2012

Fingerprint

Isoflavones
isoflavones
Estrogen Receptors
immunoglobulins
Immunoglobulins
receptors
Equol
immunoglobulin E
soybean products
daidzein
Genistein
genistein
IgE Receptors
Anti-Allergic Agents
Messenger RNA
cells
mast cells
Soybeans
Mast Cells
bone marrow

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Cite this

Isoflavones suppress the expression of the FcεRI high-affinity immunoglobulin e receptor independent of the estrogen receptor. / Yamashita, Shuya; Tsukamoto, Shuntaro; Kumazoe, Motofumi; Kim, Yoon Hee; Yamada, Koji; Tachibana, Hirofumi.

In: Journal of Agricultural and Food Chemistry, Vol. 60, No. 34, 29.08.2012, p. 8379-8385.

Research output: Contribution to journalArticle

Yamashita, Shuya ; Tsukamoto, Shuntaro ; Kumazoe, Motofumi ; Kim, Yoon Hee ; Yamada, Koji ; Tachibana, Hirofumi. / Isoflavones suppress the expression of the FcεRI high-affinity immunoglobulin e receptor independent of the estrogen receptor. In: Journal of Agricultural and Food Chemistry. 2012 ; Vol. 60, No. 34. pp. 8379-8385.
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