Isolation and structure of a galactocerebroside from the sea cucumber bohadschia argus

Yuriko Ikeda, Masanori Inagaki, Koji Yamada, Xiao Wen Zhang, Bo Zhang, Tomofumi Miyamoto, Ryuichi Higuchi

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Abstract

A galactocerebroside (BAC-4-4a) was obtained from its parent galactocerebroside molecular species (BAC-4) by using two types of reversed-phase HPLC column. The parent cerebroside BAC-4 has been isolated from less polar lipid fraction of CHCl3/MeOH extract of sea cucumber Bohadschia argus, together with known typical types of glucocerebroside molecular species. The structure of BAC-4-4a was determined on the basis of chemical and spectroscopic evidences as 1-O-(β-D-galactopyranosyl)-(25,3R, 4,E)-2[(2′R,15′Z)-2-hydroxytetracosenoyl-amino]-4-heptadecene-1, 3-diol. This is the first report of isolation and structure determination of galactocerebro-side from sea cucumber.

Original languageEnglish
Pages (from-to)315-317
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume57
Issue number3
DOIs
Publication statusPublished - Mar 1 2009

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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