Isolation and structure of biologically active gangliosides from the sea cucumber Holothuria pervicax

Koji Yamada, Yasuo Harada, Yoshiteru Nagaregawa, Tomofumi Miyamoto, Ryuichi Isobe, Ryuichi Higuchi

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Three ganglioside molecular species, HPG-8, HPG-3, and HPG-1, have been obtained from the polar fraction of the chloroform/methanol extract of the sea cucumber Holothuria pervicax. The structures of these gangliosides have been determined on the basis of chemical and spectroscopic evidence. They represent new ganglioside molecular species. HPG-8 is a sulfated monosialo-ganglioside, while HPG-3 and HPG-1 are disialo-gangliosides possessing 2→4-linked tandem-type disialosyl moieties. These three gangliosides qualitative neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cells.

Original languageEnglish
Pages (from-to)2519-2525
Number of pages7
JournalEuropean Journal of Organic Chemistry
Issue number11
DOIs
Publication statusPublished - Nov 1998

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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