Isolation and structure of biologically active gangliosides from the sea cucumber Holothuria pervicax

Koji Yamada, Yasuo Harada, Yoshiteru Nagaregawa, Tomofumi Miyamoto, Ryuichi Isobe, Ryuichi Higuchi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Three ganglioside molecular species, HPG-8, HPG-3, and HPG-1, have been obtained from the polar fraction of the chloroform/methanol extract of the sea cucumber Holothuria pervicax. The structures of these gangliosides have been determined on the basis of chemical and spectroscopic evidence. They represent new ganglioside molecular species. HPG-8 is a sulfated monosialo-ganglioside, while HPG-3 and HPG-1 are disialo-gangliosides possessing 2→4-linked tandem-type disialosyl moieties. These three gangliosides qualitative neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cells.

Original languageEnglish
Pages (from-to)2519-2525
Number of pages7
JournalEuropean Journal of Organic Chemistry
Issue number11
DOIs
Publication statusPublished - Jan 1 1998

Fingerprint

Gangliosides
chloroform
cultured cells
rats
isolation
methyl alcohol
cells
Chloroform
Methanol
Rats
Cells

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Isolation and structure of biologically active gangliosides from the sea cucumber Holothuria pervicax. / Yamada, Koji; Harada, Yasuo; Nagaregawa, Yoshiteru; Miyamoto, Tomofumi; Isobe, Ryuichi; Higuchi, Ryuichi.

In: European Journal of Organic Chemistry, No. 11, 01.01.1998, p. 2519-2525.

Research output: Contribution to journalArticle

Yamada, Koji ; Harada, Yasuo ; Nagaregawa, Yoshiteru ; Miyamoto, Tomofumi ; Isobe, Ryuichi ; Higuchi, Ryuichi. / Isolation and structure of biologically active gangliosides from the sea cucumber Holothuria pervicax. In: European Journal of Organic Chemistry. 1998 ; No. 11. pp. 2519-2525.
@article{26f595971bb946da9dea7ca4591172a8,
title = "Isolation and structure of biologically active gangliosides from the sea cucumber Holothuria pervicax",
abstract = "Three ganglioside molecular species, HPG-8, HPG-3, and HPG-1, have been obtained from the polar fraction of the chloroform/methanol extract of the sea cucumber Holothuria pervicax. The structures of these gangliosides have been determined on the basis of chemical and spectroscopic evidence. They represent new ganglioside molecular species. HPG-8 is a sulfated monosialo-ganglioside, while HPG-3 and HPG-1 are disialo-gangliosides possessing 2→4-linked tandem-type disialosyl moieties. These three gangliosides qualitative neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cells.",
author = "Koji Yamada and Yasuo Harada and Yoshiteru Nagaregawa and Tomofumi Miyamoto and Ryuichi Isobe and Ryuichi Higuchi",
year = "1998",
month = "1",
day = "1",
doi = "10.1002/(SICI)1099-0690(199811)1998:11<2519::AID-EJOC2519>3.0.CO;2-V",
language = "English",
pages = "2519--2525",
journal = "Liebigs Annalen der Chemie",
issn = "1434-193X",
publisher = "Wiley-VCH Verlag",
number = "11",

}

TY - JOUR

T1 - Isolation and structure of biologically active gangliosides from the sea cucumber Holothuria pervicax

AU - Yamada, Koji

AU - Harada, Yasuo

AU - Nagaregawa, Yoshiteru

AU - Miyamoto, Tomofumi

AU - Isobe, Ryuichi

AU - Higuchi, Ryuichi

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Three ganglioside molecular species, HPG-8, HPG-3, and HPG-1, have been obtained from the polar fraction of the chloroform/methanol extract of the sea cucumber Holothuria pervicax. The structures of these gangliosides have been determined on the basis of chemical and spectroscopic evidence. They represent new ganglioside molecular species. HPG-8 is a sulfated monosialo-ganglioside, while HPG-3 and HPG-1 are disialo-gangliosides possessing 2→4-linked tandem-type disialosyl moieties. These three gangliosides qualitative neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cells.

AB - Three ganglioside molecular species, HPG-8, HPG-3, and HPG-1, have been obtained from the polar fraction of the chloroform/methanol extract of the sea cucumber Holothuria pervicax. The structures of these gangliosides have been determined on the basis of chemical and spectroscopic evidence. They represent new ganglioside molecular species. HPG-8 is a sulfated monosialo-ganglioside, while HPG-3 and HPG-1 are disialo-gangliosides possessing 2→4-linked tandem-type disialosyl moieties. These three gangliosides qualitative neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cells.

UR - http://www.scopus.com/inward/record.url?scp=0001599248&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0001599248&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1099-0690(199811)1998:11<2519::AID-EJOC2519>3.0.CO;2-V

DO - 10.1002/(SICI)1099-0690(199811)1998:11<2519::AID-EJOC2519>3.0.CO;2-V

M3 - Article

AN - SCOPUS:0001599248

SP - 2519

EP - 2525

JO - Liebigs Annalen der Chemie

JF - Liebigs Annalen der Chemie

SN - 1434-193X

IS - 11

ER -