Isolation and structure of biologically active glycosphingolipids from the sea cucumber Cucumaria echinata

Koji Yamada, Eiji Hara, Tomofumi Miyamoto, Ryuichi Higuchi, Ryuichi Isobe, Seiichiroh Honda

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Five cerebrosides, CE-1-1, CE-1-2, CE-1-3, CE-3-1, and CE-3-2, and a ganglioside molecular species CG-1 have been obtained from the less polar and polar fractions, respectively, of the chloroform/methanol extract of the sea cucumber Cucumaria echinata. The structures of these glycosphingohpids have been determined on the basis of chemical and spectroscopic evidence. The cerebrosides show lethality toward brine shrimps. On the other hand, the ganghoside CG-1 exhibits neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cells.

Original languageEnglish
Pages (from-to)371-378
Number of pages8
JournalEuropean Journal of Organic Chemistry
Issue number2
DOIs
Publication statusPublished - Feb 1998

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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