Isolation and structure of hematoside-type ganglioside from the starfish linckia laevigata

Masanori Inagaki, Takeshi Saito, Tomofumi Miyamoto, Ryuichi Higuchi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A hematoside-type ganglioside, LLG-1 (1), has been obtained from the polar lipid fraction of the chloro- form/methanol extract of the starfish Linckia laevigata. The structure of the ganglioside has been determined on the basis of chemical and spectroscopic evidence as 1-0-[N-glycolyl-α-D-neuraminosyl- (2→3)-β-D-galactopyra-nosyl-(1→4)-β-D-glucopyranosyl] -ceramide. The ceramide moiety was composed of heterogeneous 2-hydroxy fatty acid and phytosphingosine units. This is the first report on the isolation and structure elucidation of naked hematoside-type ganglioside from echinoderms.

Original languageEnglish
Pages (from-to)204-206
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume57
Issue number2
DOIs
Publication statusPublished - Feb 1 2009

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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