A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-DI (IC<SUB>50</SUB> : 4μg/ml) and mouse mastocytoma, P-815 (IC<SUB>50</SUB> : 0.6μg/ml), but not that of Balb/c 3T3.
Kohama, Y., Teramoto, T., Iida, K., Murayama, N., Samba, T., Tatebatake, N., ... Mimura, T. (1991). Isolation of a new antitumor substance from Bacillus stearothermophilus. Chemical and Pharmaceutical Bulletin, 39(9), 2468-2470. https://doi.org/10.1248/cpb.39.2468