Isolation of a new antitumor substance from bacillus stearothermophil stearothermophilus

Yasuhiro Kohama, Tetsuyuki Teramoto, Kentaro Iida, Norihito Murayama, Yuzo Kayamori, Kazutake Tsujikawa, Tsutomu Mimura, Taro Semba, Noriko Tatebatake

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-D1 (IC50: 4 pg/ml) and mouse mastocytoma, P-815 (IC5Q: 0.6 pg/ml), but not that of Balb/c 3T3.

Original languageEnglish
Pages (from-to)2468-2470
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume39
Issue number9
DOIs
Publication statusPublished - Jan 1 1991

Fingerprint

Geobacillus stearothermophilus
Macrophages
Bacilli
Mastocytoma
Inhibitory Concentration 50
High Pressure Liquid Chromatography

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

Kohama, Y., Teramoto, T., Iida, K., Murayama, N., Kayamori, Y., Tsujikawa, K., ... Tatebatake, N. (1991). Isolation of a new antitumor substance from bacillus stearothermophil stearothermophilus. Chemical and Pharmaceutical Bulletin, 39(9), 2468-2470. https://doi.org/10.1248/cpb.39.2468

Isolation of a new antitumor substance from bacillus stearothermophil stearothermophilus. / Kohama, Yasuhiro; Teramoto, Tetsuyuki; Iida, Kentaro; Murayama, Norihito; Kayamori, Yuzo; Tsujikawa, Kazutake; Mimura, Tsutomu; Semba, Taro; Tatebatake, Noriko.

In: Chemical and Pharmaceutical Bulletin, Vol. 39, No. 9, 01.01.1991, p. 2468-2470.

Research output: Contribution to journalArticle

Kohama, Y, Teramoto, T, Iida, K, Murayama, N, Kayamori, Y, Tsujikawa, K, Mimura, T, Semba, T & Tatebatake, N 1991, 'Isolation of a new antitumor substance from bacillus stearothermophil stearothermophilus', Chemical and Pharmaceutical Bulletin, vol. 39, no. 9, pp. 2468-2470. https://doi.org/10.1248/cpb.39.2468
Kohama, Yasuhiro ; Teramoto, Tetsuyuki ; Iida, Kentaro ; Murayama, Norihito ; Kayamori, Yuzo ; Tsujikawa, Kazutake ; Mimura, Tsutomu ; Semba, Taro ; Tatebatake, Noriko. / Isolation of a new antitumor substance from bacillus stearothermophil stearothermophilus. In: Chemical and Pharmaceutical Bulletin. 1991 ; Vol. 39, No. 9. pp. 2468-2470.
@article{02db14225eac40f286cc910e3fcd9b51,
title = "Isolation of a new antitumor substance from bacillus stearothermophil stearothermophilus",
abstract = "A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-D1 (IC50: 4 pg/ml) and mouse mastocytoma, P-815 (IC5Q: 0.6 pg/ml), but not that of Balb/c 3T3.",
author = "Yasuhiro Kohama and Tetsuyuki Teramoto and Kentaro Iida and Norihito Murayama and Yuzo Kayamori and Kazutake Tsujikawa and Tsutomu Mimura and Taro Semba and Noriko Tatebatake",
year = "1991",
month = "1",
day = "1",
doi = "10.1248/cpb.39.2468",
language = "English",
volume = "39",
pages = "2468--2470",
journal = "Chemical and Pharmaceutical Bulletin",
issn = "0009-2363",
publisher = "The Pharmaceutical Society of Japan",
number = "9",

}

TY - JOUR

T1 - Isolation of a new antitumor substance from bacillus stearothermophil stearothermophilus

AU - Kohama, Yasuhiro

AU - Teramoto, Tetsuyuki

AU - Iida, Kentaro

AU - Murayama, Norihito

AU - Kayamori, Yuzo

AU - Tsujikawa, Kazutake

AU - Mimura, Tsutomu

AU - Semba, Taro

AU - Tatebatake, Noriko

PY - 1991/1/1

Y1 - 1991/1/1

N2 - A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-D1 (IC50: 4 pg/ml) and mouse mastocytoma, P-815 (IC5Q: 0.6 pg/ml), but not that of Balb/c 3T3.

AB - A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-D1 (IC50: 4 pg/ml) and mouse mastocytoma, P-815 (IC5Q: 0.6 pg/ml), but not that of Balb/c 3T3.

UR - http://www.scopus.com/inward/record.url?scp=0025940615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025940615&partnerID=8YFLogxK

U2 - 10.1248/cpb.39.2468

DO - 10.1248/cpb.39.2468

M3 - Article

C2 - 1804563

AN - SCOPUS:0025940615

VL - 39

SP - 2468

EP - 2470

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 9

ER -