Isolation of new secondary metabolites from gorgonian soft coral Heteroxenia fuscescens collected from Red Sea

Fahd M. Abdelkarem; Ezz Eldin K. Desoky; Alaa M. Nafady; Ahmed E. Allam; Aldoushy Mahdy; Maki Nagata; Tomofumi Miyamoto; Kuniyoshi Shimizu

doi:10.1016/j.phytol.2020.02.006

Isolation of new secondary metabolites from gorgonian soft coral Heteroxenia fuscescens collected from Red Sea

Fahd M. Abdelkarem, Ezz Eldin K. Desoky, Alaa M. Nafady, Ahmed E. Allam, Aldoushy Mahdy, Maki Nagata, Tomofumi Miyamoto, Kuniyoshi Shimizu

Research output: Contribution to journal › Article › peer-review

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Abstract

Further chemical study of the crude extract of the soft coral Heteroxenia fuscescens (Fam., Xeniidea), led to isolation of two new sterols, Heterofuscesterols A (1) and B (2), a sterol isolated for the first time from natural sources, 3β,5α,6β-trihydroxyandrosta-17-one (3), along with one new hydroperoxy sesquiterpene, Heterofusceterpene A (4), and one known ceramide (5). Their structures were elucidated by comprehensive spectroscopic analyses, including NMR and HRESIMS, and by comparison with previous data for related compounds in the literature. The cytotoxic activities of the isolated compounds were assessed using MTT colorimetric assay against MCF-7 and OVK-18 cancer cell lines.

Original language	English
Pages (from-to)	156-161
Number of pages	6
Journal	Phytochemistry Letters
Volume	36
DOIs	https://doi.org/10.1016/j.phytol.2020.02.006
Publication status	Published - Apr 2020

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytol.2020.02.006

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title = "Isolation of new secondary metabolites from gorgonian soft coral Heteroxenia fuscescens collected from Red Sea",

abstract = "Further chemical study of the crude extract of the soft coral Heteroxenia fuscescens (Fam., Xeniidea), led to isolation of two new sterols, Heterofuscesterols A (1) and B (2), a sterol isolated for the first time from natural sources, 3β,5α,6β-trihydroxyandrosta-17-one (3), along with one new hydroperoxy sesquiterpene, Heterofusceterpene A (4), and one known ceramide (5). Their structures were elucidated by comprehensive spectroscopic analyses, including NMR and HRESIMS, and by comparison with previous data for related compounds in the literature. The cytotoxic activities of the isolated compounds were assessed using MTT colorimetric assay against MCF-7 and OVK-18 cancer cell lines.",

author = "Abdelkarem, {Fahd M.} and Desoky, {Ezz Eldin K.} and Nafady, {Alaa M.} and Allam, {Ahmed E.} and Aldoushy Mahdy and Maki Nagata and Tomofumi Miyamoto and Kuniyoshi Shimizu",

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year = "2020",

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doi = "10.1016/j.phytol.2020.02.006",

language = "English",

volume = "36",

pages = "156--161",

journal = "Phytochemistry Letters",

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T1 - Isolation of new secondary metabolites from gorgonian soft coral Heteroxenia fuscescens collected from Red Sea

AU - Abdelkarem, Fahd M.

AU - Desoky, Ezz Eldin K.

AU - Nafady, Alaa M.

AU - Allam, Ahmed E.

AU - Mahdy, Aldoushy

AU - Nagata, Maki

AU - Miyamoto, Tomofumi

AU - Shimizu, Kuniyoshi

PY - 2020/4

Y1 - 2020/4

N2 - Further chemical study of the crude extract of the soft coral Heteroxenia fuscescens (Fam., Xeniidea), led to isolation of two new sterols, Heterofuscesterols A (1) and B (2), a sterol isolated for the first time from natural sources, 3β,5α,6β-trihydroxyandrosta-17-one (3), along with one new hydroperoxy sesquiterpene, Heterofusceterpene A (4), and one known ceramide (5). Their structures were elucidated by comprehensive spectroscopic analyses, including NMR and HRESIMS, and by comparison with previous data for related compounds in the literature. The cytotoxic activities of the isolated compounds were assessed using MTT colorimetric assay against MCF-7 and OVK-18 cancer cell lines.

AB - Further chemical study of the crude extract of the soft coral Heteroxenia fuscescens (Fam., Xeniidea), led to isolation of two new sterols, Heterofuscesterols A (1) and B (2), a sterol isolated for the first time from natural sources, 3β,5α,6β-trihydroxyandrosta-17-one (3), along with one new hydroperoxy sesquiterpene, Heterofusceterpene A (4), and one known ceramide (5). Their structures were elucidated by comprehensive spectroscopic analyses, including NMR and HRESIMS, and by comparison with previous data for related compounds in the literature. The cytotoxic activities of the isolated compounds were assessed using MTT colorimetric assay against MCF-7 and OVK-18 cancer cell lines.

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EP - 161

JO - Phytochemistry Letters

JF - Phytochemistry Letters

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Isolation of new secondary metabolites from gorgonian soft coral Heteroxenia fuscescens collected from Red Sea

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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