Isolation of new secondary metabolites from gorgonian soft coral Heteroxenia fuscescens collected from Red Sea

Fahd M. Abdelkarem, Ezz Eldin K. Desoky, Alaa M. Nafady, Ahmed E. Allam, Aldoushy Mahdy, Maki Nagata, Tomofumi Miyamoto, Kuniyoshi Shimizu

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1 Citation (Scopus)

Abstract

Further chemical study of the crude extract of the soft coral Heteroxenia fuscescens (Fam., Xeniidea), led to isolation of two new sterols, Heterofuscesterols A (1) and B (2), a sterol isolated for the first time from natural sources, 3β,5α,6β-trihydroxyandrosta-17-one (3), along with one new hydroperoxy sesquiterpene, Heterofusceterpene A (4), and one known ceramide (5). Their structures were elucidated by comprehensive spectroscopic analyses, including NMR and HRESIMS, and by comparison with previous data for related compounds in the literature. The cytotoxic activities of the isolated compounds were assessed using MTT colorimetric assay against MCF-7 and OVK-18 cancer cell lines.

Original languageEnglish
Pages (from-to)156-161
Number of pages6
JournalPhytochemistry Letters
Volume36
DOIs
Publication statusPublished - Apr 2020

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science

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