Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain

Jie Sun, Satoko Tadokoro, Takanobu Imanaka, Seiko D. Murakami, Mako Nakamura, Kouji Kashiwada, Jiae Ko, Wataru Nishida, Kenji Sobue

Research output: Contribution to journalArticle

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Abstract

Using monoclonal antibody against the 45 kDa postsynaptic density protein, we isolated a novel isoform of Homer/vesl. The NH2-terminal region containing a PDZ domain of this protein is identical to that of Homer/vesl, and the COOH-terminal region containing unique leucine zippers shows self-multimerization. We named this protein PSD-Zip45. In addition to specific binding of PSD-Zip45 mediated by a PDZ domain to the metabotropic glutamate receptors 1α or 5, the distribution of PSD-Zip45 transcripts is highly consistent with that of metabotropic glutamate receptor transcripts. The PSD-Zip45 is, therefore, the first candidate as receptor anchoring proteins containing leucine zipper motifs in the central nervous system. Copyright (C) 1998 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
JournalFEBS Letters
Volume437
Issue number3
DOIs
Publication statusPublished - Oct 23 1998

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Leucine Zippers
PDZ Domains
Rats
Brain
Metabotropic Glutamate Receptors
Proteins
Neurology
Protein Isoforms
Central Nervous System
Monoclonal Antibodies

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain. / Sun, Jie; Tadokoro, Satoko; Imanaka, Takanobu; D. Murakami, Seiko; Nakamura, Mako; Kashiwada, Kouji; Ko, Jiae; Nishida, Wataru; Sobue, Kenji.

In: FEBS Letters, Vol. 437, No. 3, 23.10.1998, p. 304-308.

Research output: Contribution to journalArticle

Sun, J, Tadokoro, S, Imanaka, T, D. Murakami, S, Nakamura, M, Kashiwada, K, Ko, J, Nishida, W & Sobue, K 1998, 'Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain', FEBS Letters, vol. 437, no. 3, pp. 304-308. https://doi.org/10.1016/S0014-5793(98)01256-3
Sun, Jie ; Tadokoro, Satoko ; Imanaka, Takanobu ; D. Murakami, Seiko ; Nakamura, Mako ; Kashiwada, Kouji ; Ko, Jiae ; Nishida, Wataru ; Sobue, Kenji. / Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain. In: FEBS Letters. 1998 ; Vol. 437, No. 3. pp. 304-308.
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