TY - JOUR
T1 - Isolation of rat mitochondrial transcription factor A (r-Tfam) cDNA
AU - Inagaki, Hidetoshi
AU - Hayashi, Toshihiko
AU - Matsushima, Yuichi
AU - Lin, Kong Hua
AU - Maeda, Sumio
AU - Ichihara, Shigeyuki
AU - Kitagawa, Yasuo
AU - Saito, Takao
PY - 2000
Y1 - 2000
N2 - We have isolated rat mitochondrial transcription factor A (Tfam; formerly known as mtTFA) cDNA clones from a rat cerebellum cDNA library using human Tfam cDNA as a probe. The deduced amino acid sequence of r-Tfam shows 62% and 89% overall identity to human and mouse Tfam, respectively. We also show the presence of two r-Tfam isoforms in testis as for mouse. Our findings suggest that the mechanisms underlying transcription of mitochondrial genes are conserved among rat, mouse, and human.
AB - We have isolated rat mitochondrial transcription factor A (Tfam; formerly known as mtTFA) cDNA clones from a rat cerebellum cDNA library using human Tfam cDNA as a probe. The deduced amino acid sequence of r-Tfam shows 62% and 89% overall identity to human and mouse Tfam, respectively. We also show the presence of two r-Tfam isoforms in testis as for mouse. Our findings suggest that the mechanisms underlying transcription of mitochondrial genes are conserved among rat, mouse, and human.
UR - http://www.scopus.com/inward/record.url?scp=0033923917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033923917&partnerID=8YFLogxK
U2 - 10.3109/10425170009033980
DO - 10.3109/10425170009033980
M3 - Article
C2 - 10902920
AN - SCOPUS:0033923917
SN - 1940-1736
VL - 11
SP - 131
EP - 135
JO - DNA Sequence - Journal of DNA Sequencing and Mapping
JF - DNA Sequence - Journal of DNA Sequencing and Mapping
IS - 1-2
ER -