Abstract
Isoprenoids are indispensable for all types of cellular life in the Archaea, Bacteria, and Eucarya. These membrane-associated molecules are involved in a wide variety of vital biological functions, ranging from compartmentalization and stability, to protection and energy-transduction. In Archaea, isoprenoid compounds constitute the hydrophobic moiety of the typical ether-linked membrane lipids. With respect to stereochemistry and composition, these archaeal lipids are very different from the ester-linked, fatty acid-based phospholipids in bacterial and eukaryotic membranes. This review provides an update on isoprenoid biosynthesis pathways, with a focus on the archaeal enzymes. The black-and-white distribution of fundamentally distinct membrane lipids in Archaea on the one hand, and Bacteria and Eucarya on the other, has previously been used as a basis for hypothetical evolutionary scenarios, a selection of which will be discussed here.
| Original language | English |
|---|---|
| Pages (from-to) | 39-52 |
| Number of pages | 14 |
| Journal | Research in Microbiology |
| Volume | 162 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2011 |
| Externally published | Yes |
Fingerprint
All Science Journal Classification (ASJC) codes
- Microbiology
- Molecular Biology
Cite this
Isoprenoid biosynthesis in Archaea - Biochemical and evolutionary implications. / Matsumi, Rie; Atomi, Haruyuki; Driessen, Arnold J.M.; van der Oost, John.
In: Research in Microbiology, Vol. 162, No. 1, 01.01.2011, p. 39-52.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isoprenoid biosynthesis in Archaea - Biochemical and evolutionary implications
AU - Matsumi, Rie
AU - Atomi, Haruyuki
AU - Driessen, Arnold J.M.
AU - van der Oost, John
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Isoprenoids are indispensable for all types of cellular life in the Archaea, Bacteria, and Eucarya. These membrane-associated molecules are involved in a wide variety of vital biological functions, ranging from compartmentalization and stability, to protection and energy-transduction. In Archaea, isoprenoid compounds constitute the hydrophobic moiety of the typical ether-linked membrane lipids. With respect to stereochemistry and composition, these archaeal lipids are very different from the ester-linked, fatty acid-based phospholipids in bacterial and eukaryotic membranes. This review provides an update on isoprenoid biosynthesis pathways, with a focus on the archaeal enzymes. The black-and-white distribution of fundamentally distinct membrane lipids in Archaea on the one hand, and Bacteria and Eucarya on the other, has previously been used as a basis for hypothetical evolutionary scenarios, a selection of which will be discussed here.
AB - Isoprenoids are indispensable for all types of cellular life in the Archaea, Bacteria, and Eucarya. These membrane-associated molecules are involved in a wide variety of vital biological functions, ranging from compartmentalization and stability, to protection and energy-transduction. In Archaea, isoprenoid compounds constitute the hydrophobic moiety of the typical ether-linked membrane lipids. With respect to stereochemistry and composition, these archaeal lipids are very different from the ester-linked, fatty acid-based phospholipids in bacterial and eukaryotic membranes. This review provides an update on isoprenoid biosynthesis pathways, with a focus on the archaeal enzymes. The black-and-white distribution of fundamentally distinct membrane lipids in Archaea on the one hand, and Bacteria and Eucarya on the other, has previously been used as a basis for hypothetical evolutionary scenarios, a selection of which will be discussed here.
UR - http://www.scopus.com/inward/record.url?scp=78751566447&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78751566447&partnerID=8YFLogxK
U2 - 10.1016/j.resmic.2010.10.003
DO - 10.1016/j.resmic.2010.10.003
M3 - Article
C2 - 21034816
AN - SCOPUS:78751566447
VL - 162
SP - 39
EP - 52
JO - Research in Microbiology
JF - Research in Microbiology
SN - 0923-2508
IS - 1
ER -