TY - JOUR
T1 - Isoprenoid biosynthesis in Archaea - Biochemical and evolutionary implications
AU - Matsumi, Rie
AU - Atomi, Haruyuki
AU - Driessen, Arnold J.M.
AU - van der Oost, John
N1 - Funding Information:
This work was supported by the European Union , as a Marie Curie Research Training Network ( MRTN-CT-2006-033499 ; SOLAR).
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/1
Y1 - 2011/1
N2 - Isoprenoids are indispensable for all types of cellular life in the Archaea, Bacteria, and Eucarya. These membrane-associated molecules are involved in a wide variety of vital biological functions, ranging from compartmentalization and stability, to protection and energy-transduction. In Archaea, isoprenoid compounds constitute the hydrophobic moiety of the typical ether-linked membrane lipids. With respect to stereochemistry and composition, these archaeal lipids are very different from the ester-linked, fatty acid-based phospholipids in bacterial and eukaryotic membranes. This review provides an update on isoprenoid biosynthesis pathways, with a focus on the archaeal enzymes. The black-and-white distribution of fundamentally distinct membrane lipids in Archaea on the one hand, and Bacteria and Eucarya on the other, has previously been used as a basis for hypothetical evolutionary scenarios, a selection of which will be discussed here.
AB - Isoprenoids are indispensable for all types of cellular life in the Archaea, Bacteria, and Eucarya. These membrane-associated molecules are involved in a wide variety of vital biological functions, ranging from compartmentalization and stability, to protection and energy-transduction. In Archaea, isoprenoid compounds constitute the hydrophobic moiety of the typical ether-linked membrane lipids. With respect to stereochemistry and composition, these archaeal lipids are very different from the ester-linked, fatty acid-based phospholipids in bacterial and eukaryotic membranes. This review provides an update on isoprenoid biosynthesis pathways, with a focus on the archaeal enzymes. The black-and-white distribution of fundamentally distinct membrane lipids in Archaea on the one hand, and Bacteria and Eucarya on the other, has previously been used as a basis for hypothetical evolutionary scenarios, a selection of which will be discussed here.
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U2 - 10.1016/j.resmic.2010.10.003
DO - 10.1016/j.resmic.2010.10.003
M3 - Article
C2 - 21034816
AN - SCOPUS:78751566447
VL - 162
SP - 39
EP - 52
JO - Research in Microbiology
JF - Research in Microbiology
SN - 0923-2508
IS - 1
ER -