We examined HLA-A, B, C, DR and immunoglobulin allotype (Gm and Km) of 23 families with 63 members where two siblings were affected with Kawasaki disease (mucocutaneous lymphnode syndrome: MCLS). Analysis of 23 probands did not confirm the statistical association of MCLS with HLA, Gm and Km. Out of 23 affected sib pairs, 4 shared two HLA haplotypes identical by discent, 12 shared one HLA haplotype and 7 shared no HLA haplotype. The distribution of HLA haplotypes shared by affected sib pairs did not significantly differ from the random distribution. Similarly, there was no distortion in the distribution of Gm haplotypes shared by the affected sib pairs. We sent questionnnaires by mail to the pediatrician of 954 hospitals all over Japan, and obtained answers reporting 122 twin pairs from 575 hospitals (60.3%) by the end of June 1984. Out of 122 twin pairs, zygosities of 97 pairs had been estimated. The twin concordance was found in 17.5% of monozygous pairs and 10.0% of dizygous pairs, the difference being not statistically significant (p=0.23). All these results seem to indicate that genetic factors might not be involved in the pathogenesis of MCLS at all. However it still, of course, exists a possibility that genetic factors involved in the pathogenesis of MCLS might be masked by massive environmental factors during the epidemic period in Japan.
|Number of pages||2|
|Journal||Japanese Journal of Human Genetics|
|Publication status||Published - Jan 1 1985|
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