Japanese cedar pollinosis and HLA-DP5

T. Hori, N. Kamikawaji, A. Kimura, T. Sone, N. Komiyama, S. Komiyama, T. Sasazuki

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Japanese cedar pollinosis is a type I allergic disease caused by Japanese cedar (Cryptomeria japonica) pollen. We investigated the association between the disease and HLA class II alleles by HLA-DNA typing using a PCR-SSOP method and found that the frequency of HLA-DP5 (DPA1(*)02022 and DPB1(*)0501) was significantly increased in the patients. To investigate whether the HLA-DP5 molecule is directly involved in the pathogenesis of the disease, Japanese cedar pollen antigen (CPAg)-specific T cell lines were established from 3 patients who possessed HLA-DP5 (DPA1(*)02022/ DPB1(*)0501). By using these CPAg-specific T cell lines and HLA class II-expressing L-cell transfectants, we found that disease-associated HLA-DP5 restricted T cells specific for CPAg existed in the patients. Furthermore, among 38 synthesized overlapping peptides spanning the entire length of one of the major Japanese cedar pollen allergens, Cry j 1, an immunodominant peptide which induced HLA-DP5 restricted Th2 was identified. These observations suggest that the HLA-DP5 may be involved, at least in part, in the pathogenesis, by helping the IgE antibody production against CPAg.

Original languageEnglish
Pages (from-to)485-491
Number of pages7
JournalTissue antigens
Volume47
Issue number6
DOIs
Publication statusPublished - Jan 1 1996

Fingerprint

Cryptomeria
Seasonal Allergic Rhinitis
Pollen
T-cells
Antigens
T-Lymphocytes
Peptides
Allergens
Immunoglobulin E
Cell Line
Histocompatibility Testing
DNA Fingerprinting
Molecules
Antibody Formation
Antibodies
DNA
Alleles
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

Cite this

Hori, T., Kamikawaji, N., Kimura, A., Sone, T., Komiyama, N., Komiyama, S., & Sasazuki, T. (1996). Japanese cedar pollinosis and HLA-DP5. Tissue antigens, 47(6), 485-491. https://doi.org/10.1111/j.1399-0039.1996.tb02590.x

Japanese cedar pollinosis and HLA-DP5. / Hori, T.; Kamikawaji, N.; Kimura, A.; Sone, T.; Komiyama, N.; Komiyama, S.; Sasazuki, T.

In: Tissue antigens, Vol. 47, No. 6, 01.01.1996, p. 485-491.

Research output: Contribution to journalArticle

Hori, T, Kamikawaji, N, Kimura, A, Sone, T, Komiyama, N, Komiyama, S & Sasazuki, T 1996, 'Japanese cedar pollinosis and HLA-DP5', Tissue antigens, vol. 47, no. 6, pp. 485-491. https://doi.org/10.1111/j.1399-0039.1996.tb02590.x
Hori T, Kamikawaji N, Kimura A, Sone T, Komiyama N, Komiyama S et al. Japanese cedar pollinosis and HLA-DP5. Tissue antigens. 1996 Jan 1;47(6):485-491. https://doi.org/10.1111/j.1399-0039.1996.tb02590.x
Hori, T. ; Kamikawaji, N. ; Kimura, A. ; Sone, T. ; Komiyama, N. ; Komiyama, S. ; Sasazuki, T. / Japanese cedar pollinosis and HLA-DP5. In: Tissue antigens. 1996 ; Vol. 47, No. 6. pp. 485-491.
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