Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14

Yusuke Takahashi, Keishi Sugimachi, Ken Yamamoto, Atsushi Niida, Teppei Shimamura, Tetsuya Sato, Masahiko Watanabe, Junichi Tanaka, Shinei Kudo, Kenichi Sugihara, Kazuo Hase, Masato Kusunoki, Kazutaka Yamada, Yasuhiro Shimada, Yoshihiro Moriya, Yutaka Suzuki, Satoru Miyano, Masaki Mori, Koshi Mimori

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Genome-wide association studies are a powerful tool for searching for disease susceptibility loci. Several studies identifying single nucleotide polymorphisms (SNP) connected intimately to the onset of colorectal cancer (CRC) have been published, but there are few reports of genome-wide association studies in Japan. To identify genetic variants that modify the risk of CRC oncogenesis, especially in the Japanese population, we performed a multi-stage genome-wide association study using a large number of samples: 1846 CRC cases and 2675 controls. We identified 4 SNP (rs7912831, rs4749812, rs7898455 and rs10905453) in chromosome region 10p14 associated with CRC; however, there are no coding or non-coding genes within this region of fairly extensive linkage disequilibrium (a 500-kb block) on 10p14. Our study revealed that the 10p14 locus is significantly correlated with susceptibility to CRC in the Japanese population, in accordance with the results of multiple studies in other races.

Original languageEnglish
Pages (from-to)2239-2247
Number of pages9
JournalCancer Science
Volume108
Issue number11
DOIs
Publication statusPublished - Nov 2017

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Genome-Wide Association Study
Colorectal Neoplasms
Chromosomes
Single Nucleotide Polymorphism
Disease Susceptibility
Linkage Disequilibrium
Population
Japan
Carcinogenesis
Genes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14. / Takahashi, Yusuke; Sugimachi, Keishi; Yamamoto, Ken; Niida, Atsushi; Shimamura, Teppei; Sato, Tetsuya; Watanabe, Masahiko; Tanaka, Junichi; Kudo, Shinei; Sugihara, Kenichi; Hase, Kazuo; Kusunoki, Masato; Yamada, Kazutaka; Shimada, Yasuhiro; Moriya, Yoshihiro; Suzuki, Yutaka; Miyano, Satoru; Mori, Masaki; Mimori, Koshi.

In: Cancer Science, Vol. 108, No. 11, 11.2017, p. 2239-2247.

Research output: Contribution to journalArticle

Takahashi, Y, Sugimachi, K, Yamamoto, K, Niida, A, Shimamura, T, Sato, T, Watanabe, M, Tanaka, J, Kudo, S, Sugihara, K, Hase, K, Kusunoki, M, Yamada, K, Shimada, Y, Moriya, Y, Suzuki, Y, Miyano, S, Mori, M & Mimori, K 2017, 'Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14', Cancer Science, vol. 108, no. 11, pp. 2239-2247. https://doi.org/10.1111/cas.13391
Takahashi, Yusuke ; Sugimachi, Keishi ; Yamamoto, Ken ; Niida, Atsushi ; Shimamura, Teppei ; Sato, Tetsuya ; Watanabe, Masahiko ; Tanaka, Junichi ; Kudo, Shinei ; Sugihara, Kenichi ; Hase, Kazuo ; Kusunoki, Masato ; Yamada, Kazutaka ; Shimada, Yasuhiro ; Moriya, Yoshihiro ; Suzuki, Yutaka ; Miyano, Satoru ; Mori, Masaki ; Mimori, Koshi. / Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14. In: Cancer Science. 2017 ; Vol. 108, No. 11. pp. 2239-2247.
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