TY - JOUR
T1 - Japanese soup stocks (katsuo-dashi and kombu-dashi) modulate food factor sensing-related gene expression in mice
AU - Murata, Motoki
AU - Nakayama, Kai
AU - Kitamura, Ryo
AU - Goto, Megumi
AU - Morozumi, Mai
AU - Yoshimoto, Takanori
AU - Marugame, Yuki
AU - Yoshitomi, Ren
AU - Yamashita, Shuya
AU - Fujimura, Yoshinori
AU - Tachibana, Hirofumi
N1 - Funding Information:
This research was supported in part by Grants-in-Aid for Scientific Research (KAKENHI) from the Japan Society for the Promotion of Science to H. Tachibana (grant number: JP15H02448 and JP20H05683 ). The authors would like to thank Enago ( www.enago.jp ) for the English language review.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/9
Y1 - 2022/9
N2 - Food factors, such as amino acids, vitamins, and polyphenols, have been reported to exert biological effects through a system that senses food factors. However, how food and its components affect food factor sensing (FFS) systems remains largely unknown. Japanese are known for their longevity, to which the unique Japanese food is believed to contribute their health. We hypothesized that the promotion of health by Japanese food was due to the enhancement of food functionality by improving FFS systems. To examine the effect of Japanese soup stocks (katsuo-dashi and kombu-dashi) on FFS-related gene expression in mice, we performed DNA microarray analysis. Katsuo-dashi upregulated the expression of 10 FFS-related genes in the quadriceps, induced and suppressed that of nine and two FFS-related genes in the small intestine, and increased two FFS-related genes in the perirenal fat, respectively. Kombu-dashi upregulated and downregulated the expression of 30 and one FFS-related genes in the quadriceps, induced and suppressed that of one and one FFS-related genes in the small intestine, and increased and reduced that of two and one FFS-related genes in the perirenal fat, respectively. These data suggest that Japanese soup stocks mediate FFS-related gene expressions and might regulate their sensitivity to food factors.
AB - Food factors, such as amino acids, vitamins, and polyphenols, have been reported to exert biological effects through a system that senses food factors. However, how food and its components affect food factor sensing (FFS) systems remains largely unknown. Japanese are known for their longevity, to which the unique Japanese food is believed to contribute their health. We hypothesized that the promotion of health by Japanese food was due to the enhancement of food functionality by improving FFS systems. To examine the effect of Japanese soup stocks (katsuo-dashi and kombu-dashi) on FFS-related gene expression in mice, we performed DNA microarray analysis. Katsuo-dashi upregulated the expression of 10 FFS-related genes in the quadriceps, induced and suppressed that of nine and two FFS-related genes in the small intestine, and increased two FFS-related genes in the perirenal fat, respectively. Kombu-dashi upregulated and downregulated the expression of 30 and one FFS-related genes in the quadriceps, induced and suppressed that of one and one FFS-related genes in the small intestine, and increased and reduced that of two and one FFS-related genes in the perirenal fat, respectively. These data suggest that Japanese soup stocks mediate FFS-related gene expressions and might regulate their sensitivity to food factors.
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U2 - 10.1016/j.ijgfs.2022.100573
DO - 10.1016/j.ijgfs.2022.100573
M3 - Article
AN - SCOPUS:85136605155
SN - 1878-450X
VL - 29
JO - International Journal of Gastronomy and Food Science
JF - International Journal of Gastronomy and Food Science
M1 - 100573
ER -