JB Special Review - Wnt Signaling: Biological Functions and Its Implications in Diseases: Context-dependent regulation of the β-catenin transcriptional complex supports diverse functions of Wnt/β-catenin signaling

Takamasa Masuda, Tohru Ishitani

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Wnt/β-catenin signaling is activated repeatedly during an animal's lifespan, and it controls gene expression through its essential nuclear effector, β-catenin, to regulate embryogenesis, organogenesis, and adult homeosta-sis. Although the β-catenin transcriptional complex has the ability to induce the expression of many genes to exert its diverse roles, it chooses and transactivates a specific gene set from among its numerous target genes depending on the context. For example, the β-catenin transcriptional complex stimulates the expression of cell cycle-related genes and consequent cell proliferation in neural progenitor cells, while it promotes the expression of neural differentiation-related genes in differentiating neurons. Recent studies using animal and cell culture models have gradually improved our understanding of the molecular basis underlying such context-dependent actions of the β-catenin transcriptional complex. Here, we describe eight mechanisms that support β-catenin-mediated context-dependent gene regulation, and their spatio-temporal regulation during vertebrate development. In addition, we discuss their contribution to the diverse functions of Wnt/β-catenin signaling.

Original languageEnglish
Pages (from-to)9-17
Number of pages9
JournalJournal of biochemistry
Volume161
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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