TY - JOUR
T1 - JB special review - Wnt signaling
T2 - Biological functions and its implications in diseases: Arl4c is a key regulator of tubulogenesis and tumourigenesis as a target gene of Wnt - β-catenin and growth factor - Ras signalling
AU - Matsumoto, Shinji
AU - Fujii, Shinsuke
AU - Kikuchi, Akira
N1 - Funding Information:
The authors' work cited in this review was supported, in part, by Grants-in-Aid for Scientific Research (JSPS KAKENHI) to A.K. (2009-11: Grant Number JP21249017) (2013-15: Grant Number JP25250018), S.M. (2011-13: Grant Number JP23790333) (2013-14: Grant Number JP25860211) and S.F. (2014-15: Grant Number JP26861547) from the Japan Society for the Promotion of Science (JSPS), by a Scientific Research on Innovative Areas grant to A.K. (2011-15: Grant Number JP23112004) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) and by grants from the Uehara Memorial Foundation.
Publisher Copyright:
© The Authors 2016. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.
PY - 2017/1
Y1 - 2017/1
N2 - Epithelial tubular morphogenesis (tubulogenesis) is a fundamental morphogenetic process of many epithelial organs. In this developmental process, epithelial cells migrate, proliferate, polarize and differentiate towards surrounding mesenchymal tissue to form tubule structures. Although epithelial tissue structures are basically stable in the postnatal period, epithelial cells regain highly proliferative and invasive potentials within mesenchymal tissue during tumour formation (tumourigenesis). Therefore, there must be a common molecular basis orchestrating the cellular behaviours involved in both tubulogenesis and tumourigenesis. ADP-ribosylation factor (Arf)-like protein 4c (Arl4c), which belongs to the small GTP-binding protein family, is expressed by the simultaneous activation of Wnt - β-catenin and growth factor - Ras-mitogen-activated protein kinase signalling, was identified as an essential regulator of tubulogenesis. Arl4c expression was also involved in the tumour formation of colorectal and lung cancers. In this review, we focus on Arl4c as a novel Wnt signal target molecule that links epithelial tubulogenesis to tumourigenesis.
AB - Epithelial tubular morphogenesis (tubulogenesis) is a fundamental morphogenetic process of many epithelial organs. In this developmental process, epithelial cells migrate, proliferate, polarize and differentiate towards surrounding mesenchymal tissue to form tubule structures. Although epithelial tissue structures are basically stable in the postnatal period, epithelial cells regain highly proliferative and invasive potentials within mesenchymal tissue during tumour formation (tumourigenesis). Therefore, there must be a common molecular basis orchestrating the cellular behaviours involved in both tubulogenesis and tumourigenesis. ADP-ribosylation factor (Arf)-like protein 4c (Arl4c), which belongs to the small GTP-binding protein family, is expressed by the simultaneous activation of Wnt - β-catenin and growth factor - Ras-mitogen-activated protein kinase signalling, was identified as an essential regulator of tubulogenesis. Arl4c expression was also involved in the tumour formation of colorectal and lung cancers. In this review, we focus on Arl4c as a novel Wnt signal target molecule that links epithelial tubulogenesis to tumourigenesis.
UR - http://www.scopus.com/inward/record.url?scp=85014520028&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014520028&partnerID=8YFLogxK
U2 - 10.1093/jb/mvw069
DO - 10.1093/jb/mvw069
M3 - Review article
C2 - 28053143
AN - SCOPUS:85014520028
VL - 161
SP - 27
EP - 35
JO - Journal of Biochemistry
JF - Journal of Biochemistry
SN - 0021-924X
IS - 1
ER -