Joint frequencies of alleles determined by separate formulations for the mating and mutation systems

Hidenori Tachida

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A method to calculate joint gene frequencies, which are the probabilities that two neutral genes taken at random from a population have certain allelic states, is developed taking into account the effects of the mating system and the mutation scheme. We assume that the mutation rates are constant in the population and that the mating system does not depend on allelic states. Under either - the condition that mutation rates are symmetric or that the mating unit is large and the mutation rate is small - the general formula is represented by two terms, one for the mating system and the other for the mutation scheme. The term for the mating system is expressed using the coancestry coefficient in the infinite allele model, and the term for the mutation scheme is a function of the eigenvalues and the eigenvectors of the mutation matrix. Several examples are presented as applications of the method, including homozygosity in a stepping-stone model with a symmetric mutation scheme.

Original languageEnglish
Pages (from-to)963-974
Number of pages12
JournalGenetics
Volume111
Issue number4
Publication statusPublished - 1985
Externally publishedYes

Fingerprint

Gene Frequency
Joints
Mutation Rate
Mutation
Population
Alleles
Genes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Joint frequencies of alleles determined by separate formulations for the mating and mutation systems. / Tachida, Hidenori.

In: Genetics, Vol. 111, No. 4, 1985, p. 963-974.

Research output: Contribution to journalArticle

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