Kamikihi-to, a Kampo medicine, ameliorates impairment of spatial memory in rats

Nobuaki Egashira, Naomi Manome, Kouji Kurauchi, Yoshiaki Matsumoto, Katsunori Iwasaki, Kenichi Mishima, Yukihiro Shoyama, Michihiro Fujiwara

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Abstract

The present study investigated the effects of Kamikihi-to (KKT), a Kampo medicine, on impairment of spatial memory in rats using an eight-arm radial maze task. Scopolamine (0.5 mg/kg, i.p.), a non-selective muscarinic receptor antagonist, and Δ9-tetrahydrocannabinol (THC; 6 mg/kg, i.p.), a principal psychoactive component of marihuana, each markedly impaired the spatial memory. KKT (1 and 3 mg/kg, p.o.) significantly improved the scopolamine-induced impairment of spatial memory. KKT (30 mg/kg, p.o.) also improved significantly the THC-induced impairment of spatial memory. Moreover, KKT (3 and 30 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M1 receptor agonist. Taken together these findings suggest that KKT is a useful drug for treating memory deficits.

Original languageEnglish
Pages (from-to)126-129
Number of pages4
JournalPhytotherapy Research
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 1 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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    Egashira, N., Manome, N., Kurauchi, K., Matsumoto, Y., Iwasaki, K., Mishima, K., Shoyama, Y., & Fujiwara, M. (2007). Kamikihi-to, a Kampo medicine, ameliorates impairment of spatial memory in rats. Phytotherapy Research, 21(2), 126-129. https://doi.org/10.1002/ptr.2034