Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats

Nobuaki Egashira, Hikari Iba, Haruna Kuwano, Rikako Kawanaka, Masaki Nagao, Hiroshi Moriyama, Takuya Watanabe, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.

Original languageEnglish
Pages (from-to)279-283
Number of pages5
JournalJournal of Pharmacological Sciences
Volume131
Issue number4
DOIs
Publication statusPublished - Aug 1 2016

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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