Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats

Nobuaki Egashira; Hikari Iba; Haruna Kuwano; Rikako Kawanaka; Masaki Nagao; Hiroshi Moriyama; Takuya Watanabe; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki

doi:10.1016/j.jphs.2016.07.007

Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats

Nobuaki Egashira, Hikari Iba, Haruna Kuwano, Rikako Kawanaka, Masaki Nagao, Hiroshi Moriyama, Takuya Watanabe, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki

Pharmacy

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Abstract

In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABA_A-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.

Original language	English
Pages (from-to)	279-283
Number of pages	5
Journal	Journal of Pharmacological Sciences
Volume	131
Issue number	4
DOIs	https://doi.org/10.1016/j.jphs.2016.07.007
Publication status	Published - Aug 1 2016

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology

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10.1016/j.jphs.2016.07.007

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title = "Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats",

abstract = "In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.",

author = "Nobuaki Egashira and Hikari Iba and Haruna Kuwano and Rikako Kawanaka and Masaki Nagao and Hiroshi Moriyama and Takuya Watanabe and Kaori Kubota and Shutaro Katsurabayashi and Katsunori Iwasaki",

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doi = "10.1016/j.jphs.2016.07.007",

language = "English",

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journal = "Journal of Pharmacological Sciences",

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T1 - Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats

AU - Egashira, Nobuaki

AU - Iba, Hikari

AU - Kuwano, Haruna

AU - Kawanaka, Rikako

AU - Nagao, Masaki

AU - Moriyama, Hiroshi

AU - Watanabe, Takuya

AU - Kubota, Kaori

AU - Katsurabayashi, Shutaro

AU - Iwasaki, Katsunori

PY - 2016/8/1

Y1 - 2016/8/1

N2 - In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.

AB - In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.

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JO - Journal of Pharmacological Sciences

JF - Journal of Pharmacological Sciences

SN - 1347-8613

IS - 4

ER -

Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats

Abstract

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