Abstract
In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.
| Original language | English |
|---|---|
| Pages (from-to) | 279-283 |
| Number of pages | 5 |
| Journal | Journal of Pharmacological Sciences |
| Volume | 131 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 1 2016 |
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All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Pharmacology
Cite this
Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats. / Egashira, Nobuaki; Iba, Hikari; Kuwano, Haruna; Kawanaka, Rikako; Nagao, Masaki; Moriyama, Hiroshi; Watanabe, Takuya; Kubota, Kaori; Katsurabayashi, Shutaro; Iwasaki, Katsunori.
In: Journal of Pharmacological Sciences, Vol. 131, No. 4, 01.08.2016, p. 279-283.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats
AU - Egashira, Nobuaki
AU - Iba, Hikari
AU - Kuwano, Haruna
AU - Kawanaka, Rikako
AU - Nagao, Masaki
AU - Moriyama, Hiroshi
AU - Watanabe, Takuya
AU - Kubota, Kaori
AU - Katsurabayashi, Shutaro
AU - Iwasaki, Katsunori
PY - 2016/8/1
Y1 - 2016/8/1
N2 - In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.
AB - In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.
UR - http://www.scopus.com/inward/record.url?scp=84992727869&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84992727869&partnerID=8YFLogxK
U2 - 10.1016/j.jphs.2016.07.007
DO - 10.1016/j.jphs.2016.07.007
M3 - Article
C2 - 27558587
AN - SCOPUS:84992727869
VL - 131
SP - 279
EP - 283
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8613
IS - 4
ER -