Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats

Nobuaki Egashira; Hikari Iba; Haruna Kuwano; Rikako Kawanaka; Masaki Nagao; Hiroshi Moriyama; Takuya Watanabe; Kaori Kubota; Shutaro Katsurabayashi; Katsunori Iwasaki

doi:10.1016/j.jphs.2016.07.007

Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats

Nobuaki Egashira, Hikari Iba, Haruna Kuwano, Rikako Kawanaka, Masaki Nagao, Hiroshi Moriyama, Takuya Watanabe, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki

Pharmacy

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABA_A-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.

Original language	English
Pages (from-to)	279-283
Number of pages	5
Journal	Journal of Pharmacological Sciences
Volume	131
Issue number	4
DOIs	https://doi.org/10.1016/j.jphs.2016.07.007
Publication status	Published - Aug 1 2016

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology

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Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats. / Egashira, Nobuaki; Iba, Hikari; Kuwano, Haruna; Kawanaka, Rikako; Nagao, Masaki; Moriyama, Hiroshi; Watanabe, Takuya; Kubota, Kaori; Katsurabayashi, Shutaro; Iwasaki, Katsunori.

In: Journal of Pharmacological Sciences, Vol. 131, No. 4, 01.08.2016, p. 279-283.

Research output: Contribution to journal › Article › peer-review

Egashira, Nobuaki ; Iba, Hikari ; Kuwano, Haruna ; Kawanaka, Rikako ; Nagao, Masaki ; Moriyama, Hiroshi ; Watanabe, Takuya ; Kubota, Kaori ; Katsurabayashi, Shutaro ; Iwasaki, Katsunori. / Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats. In: Journal of Pharmacological Sciences. 2016 ; Vol. 131, No. 4. pp. 279-283.

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abstract = "In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.",

author = "Nobuaki Egashira and Hikari Iba and Haruna Kuwano and Rikako Kawanaka and Masaki Nagao and Hiroshi Moriyama and Takuya Watanabe and Kaori Kubota and Shutaro Katsurabayashi and Katsunori Iwasaki",

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AU - Egashira, Nobuaki

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AU - Kawanaka, Rikako

AU - Nagao, Masaki

AU - Moriyama, Hiroshi

AU - Watanabe, Takuya

AU - Kubota, Kaori

AU - Katsurabayashi, Shutaro

AU - Iwasaki, Katsunori

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