Kampo medicine and new criteria for diagnosis of drug-induced liver injury: Sensitivity and specificity

Naoki Mantani; Toshiaki Kogure; Mosaburo Kainuma; Yutaka Shimada; Katsutoshi Terasawa

doi:10.2957/kanzo.45.345

Kampo medicine and new criteria for diagnosis of drug-induced liver injury: Sensitivity and specificity

Naoki Mantani, Toshiaki Kogure, Mosaburo Kainuma, Yutaka Shimada, Katsutoshi Terasawa

Research output: Contribution to journal › Article › peer-review

Abstract

Sensitivity and specificity of the new criteria for the diagnosis of drug-induced liver injury were examined among patients taking Kampo medicines. Examining the summaries of all admission records of patients from 1979 to 1999 in our department, we selected 30 summaries that described liver disorders suspected of being related to Kampo medicines. Causal relationship between lever injury and Kampo medicine was reexamined in each case. Specificity was examined using definitely unrelated group (8 cases), and sensitivity was examined using probably (2 cases) and definitely (4 cases) related groups. The sensitivity was 100% for the all criteria. The specificity was low for the all criteria, and was 25% for the original DDW-J criteria. These results suggest that the DDW-J criteria may be unreliable for the diagnosis of Kampo-medicine-induced liver injury.

Original language	English
Pages (from-to)	345-349
Number of pages	5
Journal	Acta Hepatologica Japonica
Volume	45
Issue number	7
DOIs	https://doi.org/10.2957/kanzo.45.345
Publication status	Published - Jan 1 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Hepatology

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abstract = "Sensitivity and specificity of the new criteria for the diagnosis of drug-induced liver injury were examined among patients taking Kampo medicines. Examining the summaries of all admission records of patients from 1979 to 1999 in our department, we selected 30 summaries that described liver disorders suspected of being related to Kampo medicines. Causal relationship between lever injury and Kampo medicine was reexamined in each case. Specificity was examined using definitely unrelated group (8 cases), and sensitivity was examined using probably (2 cases) and definitely (4 cases) related groups. The sensitivity was 100% for the all criteria. The specificity was low for the all criteria, and was 25% for the original DDW-J criteria. These results suggest that the DDW-J criteria may be unreliable for the diagnosis of Kampo-medicine-induced liver injury.",

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AU - Terasawa, Katsutoshi

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AB - Sensitivity and specificity of the new criteria for the diagnosis of drug-induced liver injury were examined among patients taking Kampo medicines. Examining the summaries of all admission records of patients from 1979 to 1999 in our department, we selected 30 summaries that described liver disorders suspected of being related to Kampo medicines. Causal relationship between lever injury and Kampo medicine was reexamined in each case. Specificity was examined using definitely unrelated group (8 cases), and sensitivity was examined using probably (2 cases) and definitely (4 cases) related groups. The sensitivity was 100% for the all criteria. The specificity was low for the all criteria, and was 25% for the original DDW-J criteria. These results suggest that the DDW-J criteria may be unreliable for the diagnosis of Kampo-medicine-induced liver injury.

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